NDLI: Atomic charges of individual reactive chemicals in binary mixtures determine their joint effects: an example of cyanogenic toxicants and aldehydes.

Please wait, while we are loading the content...

Assessing environmental contamination around obsolete pesticide stockpiles in West Africa: using the Nile monitor (Varanus niloticus) as a sentinel species.

Development and application of whole-sediment toxicity test using immobilized freshwater microalgae Pseudokirchneriella subcapitata

The role of the characteristics of humic substances in binding with benzo[h]quinoline.

Integrated ecological risk assessment of pesticides in tropical ecosystems: a case study with carbofuran in Brazil.

Evaluating the polar organic chemical integrative sampler for the monitoring of beta-blockers and hormones in wastewater treatment plant effluents and receiving surface waters.

Phytotoxkit: a critical look at a rapid assessment tool.

Bad habits die hard: the NOEC's persistence reflects poorly on ecotoxicology.

Baseline characteristics and statistical implications for the OECD 210 fish early-life stage chronic toxicity test.

Myriophyllum aquaticum versus Lemna minor: sensitivity and recovery potential after exposure to atrazine.

Biodegradation of the ultraviolet filter benzophenone-3 under different redox conditions.

Transplacental transfer of polychlorinated biphenyls and polybrominated diphenyl ethers in arctic beluga whales (Delphinapterus leucas).

Effects of dietary exposure of mink (Mustela vison) to 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrachlorodibenzofuran on reproduction and offspring viability and growth.

Hepatic retinoid levels in seven fish species (teleosts) from a tropical coastal lagoon receiving effluents from iron-ore mining and processing.

Detection of retinoic acid receptor agonistic activity and identification of causative compounds in municipal wastewater treatment plants in Japan.

Passive sampling provides evidence for Newark Bay as a source of polychlorinated dibenzo-p-dioxins and furans to the New York/New Jersey, USA, atmosphere.

Validating potential toxicity assays to assess petroleum hydrocarbon toxicity in polar soil.

Changes in liquid water alter nutrient bioavailability and gas diffusion in frozen antarctic soils contaminated with petroleum hydrocarbons.

Effects of chronic polybrominated diphenyl ether exposure on gonadal development in the northern leopard frog, Rana pipiens.

Fate of triclosan and triclocarban in soil columns with and without biosolids surface application.

Dissolved organic carbon reduces the toxicity of aluminum to three tropical freshwater organisms

Challenges for the development of a biotic ligand model predicting copper toxicity in estuaries and seas.

Predicting effects of cations on copper toxicity to lettuce (Lactuca sativa) by the biotic ligand model

High polybrominated diphenyl ether levels in California house cats: house dust a primary source?

Atomic charges of individual reactive chemicals in binary mixtures determine their joint effects: an example of cyanogenic toxicants and aldehydes.

Epigenetics for ecotoxicologists.

Year: 2012 Volume: 31 Issue: 1

Year: 2011 Volume: 30

Year: 2010 Volume: 29

Year: 2009 Volume: 28

Year: 2008 Volume: 27

Year: 2007 Volume: 26

Year: 2006 Volume: 25

Year: 2004 Volume: 23

Atomic charges of individual reactive chemicals in binary mixtures determine their joint effects: an example of cyanogenic toxicants and aldehydes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tian, Dayong Lin, Zhifen Yin, Daqiang Zhang, Yalei Kong, Deyang
Description	Country affiliation: China Author Affiliation: Tian D ( State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, China.)
Abstract	Environmental contaminants are usually encountered as mixtures, and many of these mixtures yield synergistic or antagonistic effects attributable to an intracellular chemical reaction that pose a potential threat on ecological systems. However, how atomic charges of individual chemicals determine their intracellular chemical reactions, and then determine the joint effects for mixtures containing reactive toxicants, is not well understood. To address this issue, the joint effects between cyanogenic toxicants and aldehydes on Photobacterium phosphoreum were observed in the present study. Their toxicological joint effects differed from one another. This difference is inherently related to the two atomic charges of the individual chemicals: the oxygen charge of -CHO (O(aldehyde toxicant)) in aldehyde toxicants and the carbon-atom charge of a carbon chain in the cyanogenic toxicant (C(cyanogenic toxicant)). Based on these two atomic charges, the following QSAR (quantitative structure-activity relationship) model was proposed: When (O(aldehyde toxicant) -C(cyanogenic toxicant) )> -0.125, the joint effect of equitoxic binary mixtures at median inhibition (TU, the sum of toxic units) can be calculated as TU = 1.00 ± 0.20; when (O(aldehyde toxicant) -C(cyanogenic toxicant) ) ≤ -0.125, the joint effect can be calculated using TU = - 27.6 x O (aldehyde toxicant) - 5.22 x C (cyanogenic toxicant) - 6.97 (n = 40, r = 0.887, SE = 0.195, F = 140, p < 0.001, q(2) (Loo) = 0.748; SE is the standard error of the regression, F is the F test statistic). The result provides insight into the relationship between the atomic charges and the joint effects for mixtures containing cyanogenic toxicants and aldehydes. This demonstrates that the essence of the joint effects resulting from intracellular chemical reactions depends on the atomic charges of individual chemicals. The present study provides a possible approach for the development of a QSAR model for mixtures containing reactive toxicants based on the atomic charges.
File Format	HTM / HTML
ISSN	07307268
Issue Number	2
Volume Number	31
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2012-02-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Toxicity Discipline Environmental Health Discipline Toxicology Cyanides Hazardous Substances Aldehydes Carbon Drug Effects Journal Article Quantitative Structure-activity Relationship Chemistry Discipline Chemistry Nitriles Photobacterium
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Study on the variation rules of the joint effects for multicomponent mixtures containing cyanogenic toxicants and aldehydes based on the transition state theory.

Hydrogen cyanide and cyanides :: human health aspects

Exploring QSTR analysis of the toxicity of phenols and thiophenols using machine learning methods.

The joint effects on Photobacterium phosphoreum of metal oxide nanoparticles and their most likely coexisting chemicals in the environment.

Salinity changes impact of hazardous chemicals in Enchytraeus albidus.

Effect of humic substances on toxicity of inorganic oxidizer bioluminescent monitoring.

Quantitative structure-activity relationship analysis of acute toxicity of diverse chemicals to Daphnia magna with whole molecule descriptors.

An indicator for effects of organic toxicants on lotic invertebrate communities: Independence of confounding environmental factors over an extensive river continuum.

PETROTOX: an aquatic toxicity model for petroleum substances.

Atomic charges of individual reactive chemicals in binary mixtures determine their joint effects: an example of cyanogenic toxicants and aldehydes.

Similar Documents

Study on the variation rules of the joint effects for multicomponent mixtures containing cyanogenic toxicants and aldehydes based on the transition state theory.

Hydrogen cyanide and cyanides :: human health aspects

Exploring QSTR analysis of the toxicity of phenols and thiophenols using machine learning methods.

The joint effects on Photobacterium phosphoreum of metal oxide nanoparticles and their most likely coexisting chemicals in the environment.

Salinity changes impact of hazardous chemicals in Enchytraeus albidus.

Effect of humic substances on toxicity of inorganic oxidizer bioluminescent monitoring.

Quantitative structure-activity relationship analysis of acute toxicity of diverse chemicals to Daphnia magna with whole molecule descriptors.

An indicator for effects of organic toxicants on lotic invertebrate communities: Independence of confounding environmental factors over an extensive river continuum.

PETROTOX: an aquatic toxicity model for petroleum substances.

Atomic charges of individual reactive chemicals in binary mixtures determine their joint effects: an example of cyanogenic toxicants and aldehydes.