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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Olmstead, Allen W. Kosian, Patricia A. Johnson, Rodney Blackshear, Pamela E. Haselman, Jonathan Blanksma, Chad Korte, Joseph J. Holcombe, Gary W. Burgess, Emily Lindberg-Livingston, Annelie Bennett, Blake A. Woodis, Kacie K. Degitz, Sigmund J. |
| Description | Country affiliation: United States Author Affiliation: Olmstead AW ( National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Duluth, Minnesota, USA. allen.olmstead@bayer.com) |
| Abstract | Trenbolone is an androgen agonist used in cattle production and has been measured in aquatic systems associated with concentrated animal-feeding operations. In this study, the authors characterized the effects of aqueous exposure to 17ß-trenbolone during larval Xenopus tropicalis development. Trenbolone exposure resulted in increased mortality of post-Nieuwkoop-Faber stage 58 tadpoles at concentrations ≥100 ng/L. Morphological observations and the timing of this mortality are consistent with hypertrophy of the larynx. Development of nuptial pads, a male secondary sex characteristic, was induced in tadpoles of both sexes at 100 ng/L. Effects on time to complete metamorphosis or body sizes were not observed; however, grow-outs placed in clean media for six weeks were significantly smaller in body size at 78 ng/L. Effects on sex ratios were equivocal, with the first experiment showing a significant shift in sex ratio toward males at 78 ng/L. In the second experiment, no significant effects were observed up to 100 ng/L, although overall sex ratios were similar. Histological assessment of gonads at metamorphosis showed half with normal male phenotypes and half that possessed a mixed-sex phenotype at 100 ng/L. Hypertrophy of the Wolffian ducts was also observed at this concentration. These results indicate that larval 17ß-trenbolone exposure results in effects down to 78 ng/L, illustrating potential effects from exposure to androgenic compounds in anurans. |
| File Format | HTM / HTML |
| ISSN | 07307268 |
| Issue Number | 10 |
| Volume Number | 31 |
| e-ISSN | 15528618 |
| Journal | Environmental Toxicology and Chemistry |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2012-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Water Pollutants, Chemical Xenopus Toxicity Body Size Discipline Environmental Health Trenbolone Acetate Anabolic Agents Discipline Toxicology Male Sex Differentiation Drug Effects Journal Article Sex Ratio Growth & Development Metamorphosis, Biological Animals Larva Toxicity Tests, Subacute Discipline Chemistry Female Gonads |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Health, Toxicology and Mutagenesis |
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