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Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tamaki, Motoyuki Shimizu, Tomoaki Kanazawa, Akio Tamura, Yoshifumi Hanzawa, Ayame Ebato, Chie Itou, Chiharu Yasunari, Eisuke Sanke, Haruna Abe, Hiroko Kawai, Junko Okayama, Kaede Matsumoto, Kazuhisa Komiya, Koji Kawaguchi, Minako Inagaki, Noriko Watanabe, Takahiro Kanazawa, Yoshie Hirose, Takahisa Kawamori, Ryuzo Watada, Hirotaka
Description	Country affiliation: Japan Author Affiliation: Tamaki M ( Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.)
Abstract	To our knowledge, there is currently no insulin infusion protocol for critically ill patients especially designed for Asian diabetics although many such protocols are used in Western countries. In this study, we modified the Yale insulin infusion protocol taking into consideration the characteristics of Japanese diabetics and hospital environment. We tested the modified protocol in 40 type 2 diabetic patients after elective open-heart surgery (MY group) comparing with 35 type 2 diabetic patients under empirical blood glucose control (EC group). Analyses of 1656 blood glucose measurements during insulin infusion revealed that percentage of samples that showed achievement of target blood glucose level (80-140 mg/dl) was higher under MY (78+/-15%, n=870) than EC (57+/-23%, n=786, p<0.0001). On the other hand, the percentage of samples in which blood glucose was less than 60 mg/dl was comparable in the two groups (MY: 0.5+/-5.9 per thousand, EC: 5.1+/-18.5 per thousand). None of the patients with hypoglycemia showed significant clinical adverse effects. In conclusion, our modified Yale insulin infusion protocol is effective and safe for tight blood glucose control in Japanese diabetic patients after open-heart surgery.
File Format	HTM / HTML
ISSN	01688227
Issue Number	3
Volume Number	81
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2008-09-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Therapy Humans Middle Aged Critical Illness Male Journal Article Hypoglycemic Agents Cardiac Surgical Procedures Surgery Insulin Infusion Systems Female Safety Drug Therapy Postoperative Period Blood Glucose Treatment Outcome Metabolism Randomized Controlled Trial Drug Effects Insulin Standards Therapeutic Use Discipline Endocrinology Aged Diabetic Angiopathies Elective Surgical Procedures
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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Efficacy and safety of an insulin infusion protocol during and after cardiac surgery.

SAFETY AND EFFICACY OF A PERI-OPERATIVE PROTOCOL FOR PATIENTS WITH DIABETES TREATED WITH CONTINUOUS SUBCUTANEOUS INSULIN INFUSION WHO ARE ADMITTED FOR SAME-DAY SURGERY.

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Continuous postoperative insulin infusion reduces deep sternal wound infection in patients with diabetes undergoing coronary artery bypass grafting using bilateral internal mammary artery grafts: a propensity-matched analysis.

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Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery.

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SAFETY AND EFFICACY OF A PERI-OPERATIVE PROTOCOL FOR PATIENTS WITH DIABETES TREATED WITH CONTINUOUS SUBCUTANEOUS INSULIN INFUSION WHO ARE ADMITTED FOR SAME-DAY SURGERY.

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Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery.