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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hayashino, Yasuaki Fukuhara, Shunichi Akizawa, Tadao Asano, Yasushi Wakita, Takafumi Onishi, Yoshihiro Kurokawa, Kiyoshi |
| Description | Country affiliation: Japan Author Affiliation: Hayashino Y ( Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606-8501, Japan. hayasino-y@umin.net) |
| Abstract | AIMS: AST-120, an oral adsorbent currently on-label only in Asian countries with phase III trials ongoing in the US, slows renal disease progression in patients with diabetes and advanced-stage chronic kidney disease (CKD). The objective of this study is to evaluate the cost-effectiveness of using AST-120 to treat patients with type 2 diabetes and advanced-stage CKD. METHODS: We used Markov model simulating the progression of diabetic nephropathy. Data were obtained from randomized trials estimating the progression of diabetic nephropathy with and without AST-120, and published literature. The base population was patients 60 years of age with type 2 diabetes and Stages 3 and 4 CKD. RESULTS: Treating patients with diabetes and advanced-stage CKD was found to be a dominant strategy, and quality of life improved further and more money was saved (0.22 quality-adjusted life years [QALYs] and \$15,019 per patient) using AST-120 than the control strategy. Sensitivity analysis results were robust with regard to cost, adherence, and quality of life associated with AST-120 therapy, as well as age at diagnosis. The model was relatively sensitive to the effectiveness of AST-120. CONCLUSIONS: Treating patients with type 2 diabetes and advanced-stage CKD with AST-120 appears to extend life and reduce costs. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Issue Number | 2 |
| Volume Number | 90 |
| e-ISSN | 18728227 |
| Journal | Diabetes Research and Clinical Practice |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-11-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Humans Oxides Cost-benefit Analysis Journal Article Quality Of Life Diabetes Mellitus, Type 2 Economics Creatinine Renal Insufficiency, Chronic Diabetic Nephropathies Administration, Oral Complications Prevention & Control Hemoglobin A, Glycosylated Mortality Drug Therapy Administration & Dosage Metabolism Randomized Controlled Trial Carbon Therapeutic Use Discipline Endocrinology Cost Of Illness Aged Kidney Failure, Chronic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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