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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Maharlooei, Mohsen Khosravi Bagheri, Mansooreh Solhjou, Zhabiz Jahromi, Behnam Moein Akrami, Majid Rohani, Lili Monabati, Ahmad Noorafshan, Ali Omrani, Gholamhossein Ranjbar |
| Description | Country affiliation: Iran Author Affiliation: Maharlooei MK ( Cell and Molecular Medicine Research Group, Student Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.) |
| Abstract | AIMS: Stem cells are a new hope to ameliorate impaired diabetic wound healing. The purpose of this study was to evaluate the effect of adipose tissue derived mesenchymal stem cells (AD-MSCs) on wound healing in a diabetic rat model. METHODS: Twenty-six rats became diabetic by a single intraperitoneal injection of streptozotocin. Six rats served as non-diabetic (non-DM). Diabetic rats were divided into two equal groups randomly; control and treatment. Six weeks later, a full-thickness circular excisional wound was created on the dorsum of each rat. AD-MSCs were injected intra-dermally around the wounds of treatment group. PBS was applied to control and non-DM groups. The wound area was measured every other day. After wound healing completion, full thickness skin samples were taken from the wound sites for evaluation of volume density of collagen fibers, length and volume density of vessels, and numerical density of fibroblasts by stereological methods. RESULTS: AD-MSCs accelerated wound healing rate in diabetic rats, but did not increase length and volume density of the vessels and volume density of the collagen fibers. AD-MSCs decreased the numerical density of fibroblasts. CONCLUSIONS: We concluded that AD-MSCs enhances diabetic wound healing rate probably by other mechanisms rather than enhancing angiogenesis or accumulating collagen fibers. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Issue Number | 2 |
| Volume Number | 93 |
| e-ISSN | 18728227 |
| Journal | Diabetes Research and Clinical Practice |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-08-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Cytology Rats Wound Healing Chemically Induced Journal Article Pathology Animals Mesenchymal Stromal Cells Discipline Endocrinology Diabetes Mellitus, Experimental Collagen Fibroblasts Physiology Skin Adipose Tissue Mesenchymal Stem Cell Transplantation Injuries Neovascularization, Physiologic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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