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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Monami, Matteo Dicembrini, Ilaria Nardini, Camilla Fiordelli, Irene Mannucci, Edoardo |
| Description | Country affiliation: Italy Author Affiliation: Monami M ( Section of Geriatric Cardiology and Medicine, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy.); Dicembrini I ( Obesity Agency, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy); Nardini C ( Section of Geriatric Cardiology and Medicine, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy.); Fiordelli I ( Section of Geriatric Cardiology and Medicine, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy.); Mannucci E ( Diabetes Agency, Careggi Teaching Hospital, Via delle Oblate 4, 50141 Florence, Italy. Electronic address: edoardo.mannucci@unifi.com.) |
| Abstract | AIMS: Several randomized trials with metabolic outcomes have reported that glucagon like peptide-1 receptor agonists (GLP-1 RA) could be associated with an increased risk of pancreatitis. The present meta-analysis aimed to examine this hypothesis. METHODS: An extensive Medline, Embase, and Cochrane Database search for 'exenatide', 'liraglutide', 'albiglutide', 'taspoglutide', 'dulaglutide', 'lixisenatide', and 'semaglutide' was performed up to March 31st, 2013. INCLUSION CRITERIA: (i) randomized trials, (ii) duration ≥12 weeks; (iii) on type 2 diabetes; and (iv) comparison of GLP-1RA with placebo or active drugs. Mantel-Haenszel odds ratio with 95% confidence interval (MH-OR) was calculated for pancreatitis. RESULTS: 80 eligible trials were identified. Of these, 39 had not disclosed their findings or did not report any information on pancreatitis. The remaining 41 trials enrolled 14,972 patients, with a total exposure of 14,333 patient × years (8353 and 5980 patient × years for GLP-1 receptor agonists and comparators, respectively). The overall risk of pancreatitis was not different between GLP-1RA and comparators (MH-OR: 1.01[0.37; 2.76]; p = 0.99). CONCLUSIONS: The present meta-analysis does not suggest any increase in the risk of pancreatitis with the use of GLP-1RA. However, it should be recognized that the number of observed cases of incident pancreatitis is very small and the confidence intervals of risk estimates are wide. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Issue Number | 2 |
| Volume Number | 103 |
| e-ISSN | 18728227 |
| Journal | Diabetes Research and Clinical Practice |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-02-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Adverse Effects Peptides Humans Drug Therapy Pancreatitis Glucagon-like Peptide 1 Review Receptors, Glucagon Chemically Induced Therapeutic Use Journal Article Meta-analysis Hypoglycemic Agents Discipline Endocrinology Randomized Controlled Trials As Topic Venoms Agonists Glucagon-like Peptide-1 Receptor Diabetes Mellitus, Type 2 Analogs & Derivatives Liraglutide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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