NDLI: C-reactive protein and migraine. Facts or speculations?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lippi, Giuseppe Mattiuzzi, Camilla Cervellin, Gianfranco
Abstract	Abstract Migraine is a highly prevalent and frequently disabling disorder. Since the pathogenesis of this condition has a strong inflammatory component and migraine is significantly associated with cardiovascular disease, we assess whether C-reactive protein (CRP) may be epidemiologically or casually linked with migraine. An electronic search on Medline, Scopus and Web of Science produced 17 studies reporting original data about the epidemiological association between CRP and migraine (1 retrospective, 1 interventional, 14 cross-sectional and 1 both interventional and cross-sectional). When all studies reporting sufficient data about CRP values were pooled (n=12; 6980 cases and 38,975 controls), the concentration of CRP was found to be significantly higher in patients with migraine than in controls (weighted mean difference 1.12 mg/L; 95% CI 1.01-1.25 mg/L; p<0.001). In further analysis of studies containing separate data for migraine with and without aura (n=7), CRP values remained significantly higher in both migraineur patients with aura (n=1939; weighted mean difference 0.88 mg/L; 95% CI 0.63-1.14 mg/L; p<0.001) or without aura (n=2483; weighted mean difference 1.04 mg/L; 95% CI 0.78-1.30 mg/L; p<0.001) when compared with controls (n=29,354). Despite a large inter-study heterogeneity (99.3%), our analysis provides evidence of a potential epidemiological association between increased concentration of CRP and migraine, thus paving the way for further clinical investigations about therapeutic agents that may contextually decrease the risk of cardiovascular disease and reduce the burden of migraine.
File Format	HTM / HTML
ISSN	14346621
Issue Number	9
Volume Number	52
e-ISSN	14374331
Journal	Clinical Chemistry and Laboratory Medicine
Language	English
Publisher	Walter de Gruyter
Publisher Date	2014-09-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Inflammation Mediators Discipline Clinical chemistry Biological Markers Humans Risk Factors Male Review Metabolism Epidemiology Blood Journal Article Meta-analysis Discipline Clinical Chemistry Migraine Disorders Etiology C-reactive Protein Female
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Clinical Biochemistry

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