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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chan, Dick C. Lambert, Gilles Barrett, P. Hugh R. Rye, Kerry-Anne Ooi, Esther M. M. Watts, Gerald F. |
| Description | Country affiliation: Australia Author Affiliation: Chan DC ( Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, WA6847, Australia.) |
| Abstract | BACKGROUND: Experimental studies suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator of LDL metabolism because of its ability to facilitate degradation of the LDL receptor. We investigated the association between plasma PCSK9 concentration and LDL apolipoprotein B-100 (apo B-100) metabolism in men with a wide range of body mass index values. METHODS: We used GC-MS to study the kinetics of LDL apo B-100 after intravenous administration of deuterated leucine and analyzed the data by compartmental modeling. The plasma PCSK9 concentration was measured by ELISA. RESULTS: Univariate regression analysis revealed the plasma PCSK9 concentration to be significantly and positively correlated with cholesterol (r = 0.543; P = 0.011), LDL cholesterol (r = 0.543; P = 0.011), apo B-100 (r = 0.548; P = 0.010), and LDL apo B-100 concentrations (r = 0.514; P = 0.023), and inversely correlated with the LDL apo B-100 fractional catabolic rate (FCR) (r = -0.456; P = 0.038). The association between plasma PCSK9 concentration and the LDL apo B-100 FCR remained statistically significant after adjusting for age, obesity, plasma insulin, homeostasis model assessment score, and dietary energy; however, this association had borderline significance after adjusting for plasma lathosterol. CONCLUSIONS: In men, variation in plasma PCSK9 concentration influences the catabolism of LDL apo B-100. This finding appears to be independent of obesity, insulin resistance, energy intake, and age. |
| File Format | HTM / HTML |
| ISSN | 00099147 |
| e-ISSN | 15308561 |
| Journal | Clinical Chemistry |
| Issue Number | 11 |
| Volume Number | 55 |
| Language | English |
| Publisher | American Association for Clinical Chemistry |
| Publisher Date | 2009-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Body Mass Index Research Support, Non-u.s. Gov't Biological Markers Gas Chromatography-mass Spectrometry Apolipoprotein B-100 Cholesterol, Ldl Discipline Laboratory Medicine Metabolism Insulin Blood Cholesterol Discipline Clinical Chemistry Serine Endopeptidases Proprotein Convertases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry |
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