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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Adachi, Taichi Nakanishi, Michio Otsuka, Yoritaka Nishimura, Kunihiro Hirokawa, Gou Goto, Yoichi Nonogi, Hiroshi Iwai, Naoharu |
| Description | Country affiliation: Japan Author Affiliation: Adachi T ( Department of Cardiology, National Cardiovascular Center, Suita, Osaka, Japan.) |
| Abstract | BACKGROUND: MicroRNAs (miRNAs) are endogenous small RNAs 21-25 nucleotides in length. Recently, we reported that miRNA 208 (miR-208) is produced exclusively in the rat myocardium and that plasma miR-208 is a biomarker of myocardial injury in rats. In the present study, we assessed the hypothesis that plasma concentrations of myocardial-specific miRNAs can be used to diagnose myocardial injury in humans. METHODS: We used array analysis of miRNA production in various human tissues to identify heart-specific miRNAs. We assessed the plasma concentrations of miR-499 in 14 individuals with acute coronary syndromes, 15 individuals with congestive heart failure, and 10 individuals without cardiovascular diseases. Plasma miR-499 concentrations were measured with a real-time reverse-transcription PCR method that used an artificial small RNA as an internal calibrator. RESULTS: The miRNA array analysis of various human tissues indicated that miR-499 was produced almost exclusively in the heart. Plasma miR-499 concentrations were measurably increased in all individuals with acute myocardial infarction but were below the limit of detection for all individuals in the other patient groups. CONCLUSIONS: The plasma concentration of miR-499 may be a useful biomarker of myocardial infarction in humans. |
| File Format | HTM / HTML |
| ISSN | 00099147 |
| e-ISSN | 15308561 |
| Journal | Clinical Chemistry |
| Issue Number | 7 |
| Volume Number | 56 |
| Language | English |
| Publisher | American Association for Clinical Chemistry |
| Publisher Date | 2010-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Micrornas Research Support, Non-u.s. Gov't Biological Markers Discipline Laboratory Medicine Metabolism Blood Myocardial Infarction Discipline Clinical Chemistry Myocardium Diagnosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Clinical Biochemistry |
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