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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cardinali, B. Cappella, M. Provenzano, C. Garcia-Manteiga, J. M. Lazarevic, D. Cittaro, D. Martelli, F. Falcone, G. |
| Description | Country affiliation: Italy Author Affiliation: Cardinali B ( Institute of Cell Biology and Neurobiology, National Research Council, Monterotondo Scalo, Rome, Italy.); Cappella M ( Institute of Cell Biology and Neurobiology, National Research Council, Monterotondo Scalo, Rome, Italy.); Provenzano C ( DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy.); Garcia-Manteiga JM ( Institute of Cell Biology and Neurobiology, National Research Council, Monterotondo Scalo, Rome, Italy.); Lazarevic D ( Center For Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy.); Cittaro D ( Center For Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy.); Martelli F ( Center For Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy.); Falcone G ( Molecular Cardiology Laboratory, Policlinico San Donato-IRCCS, San Donato Milanese, Milan, Italy.) |
| Abstract | A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldown followed by RNA sequencing, combined with in silico microRNA target prediction, we have identified two new targets of microRNA-222 involved in the regulation of myogenic differentiation, Ahnak and Rbm24. Specifically, the RNA-binding protein Rbm24 is a major regulator of muscle-specific alternative splicing and its downregulation by microRNA-222 results in defective exon inclusion impairing the production of muscle-specific isoforms of Coro6, Fxr1 and NACA transcripts. Reconstitution of normal levels of Rbm24 in cells overexpressing microRNA-222 rescues muscle-specific splicing. In conclusion, we have identified a new function of microRNA-222 leading to alteration of myogenic differentiation at the level of alternative splicing, and we provide evidence that this effect is mediated by Rbm24 protein. |
| File Format | HTM / HTML |
| e-ISSN | 20414889 |
| DOI | 10.1038/cddis.2016.10 |
| Journal | Cell Death and Disease |
| Volume Number | 7 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-02-04 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology |
| Content Type | Text |
| Resource Type | Article |
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