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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | de Menthon, Mathilde Lavalley, Michael P. Maldini, Carla Guillevin, Loïc Mahr, Alfred |
| Description | Country affiliation: France Author Affiliation: de Menthon M ( Hôpital Cochin) |
| Abstract | OBJECTIVE: To quantify by meta-analysis the genetic effect of the HLA-B5 or HLA-B51 (HLA-B51/B5) allele on the risk of developing Behçet's disease (BD) and to look for potential effect modifiers. METHODS: Relevant studies were identified using the PubMed Medline database and manual searches of the literature. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the random-effects model. Subgroup meta-analyses and meta-regression analyses were undertaken to investigate the effects of selected study-level parameters on the pooled OR. Heterogeneity was assessed using the I2 statistic. Pooled results were used to calculate population-attributable risks (PAR) for BD in relationship to HLA-B51/B5. RESULTS: A total of 4,800 patients with BD and 16,289 controls from 78 independent studies (published 1975-2007) were selected. The pooled OR of HLA-B51/B5 allele carriers to develop BD compared with noncarriers was 5.78 (95% CI 5.00-6.67), with moderate between-study heterogeneity (I2 = 61%). The subgroup analyses stratifying studies by geographic locations (Eastern Asia, Middle East/North Africa, Southern Europe, Northern/Eastern Europe) yielded consistent OR ranges (5.31-7.20), with I2 ranges of 52-70%. Univariate random-effects meta-regression indicated the percentage of male BD cases (P = 0.008) as a source of heterogeneity. The PAR within the various geographic areas were estimated at 32-52%. CONCLUSION: The strength of the association between BD and HLA-B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD. Variations according to sex support an interaction of this allele with BD characteristics. |
| File Format | HTM / HTML |
| ISSN | 00043591 |
| e-ISSN | 15290131 |
| DOI | 10.1002/art.24642 |
| Journal | Arthritis & Rheumatism |
| Issue Number | 10 |
| Volume Number | 61 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-10-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Global Health Risk Factors Ethnology Behcet Syndrome Hla-b Antigens Genetic Predisposition To Disease Meta-analysis Immunology Hla-b51 Antigen Genetics Heterozygote Databases, Bibliographic Odds Ratio Discipline Rheumatic Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Pharmacology (medical) Rheumatology |
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