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Year: 2009 Volume: 62 Issue: 2

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Year: 2008 Volume: 61

Year: 2008 Volume: 60

Penis allotransplantation model in the rat.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sonmez, Erhan Nasir, Serdar Siemionow, Maria
Description	Country affiliation: United States Author Affiliation: Sonmez E ( Department of Plastic Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.)
Abstract	In this study we present the first experimental vascularized penile allogenic transplantation model in the rat. In group 1 (n = 6), the vascular anatomy of the male rat perineal region was determined. In 12 Lewis rats of group 2 (n = 24), the penile composite graft was transplanted as isotransplant by microvascular anastomosis of the pedicle of the penis to the saphenous vessels and in another 12 Lewis rats of group 2, penile composite graft was transplanted without vascular anastomosis. In group 3 (n = 12), penis composite graft was transplanted from 6 Lewis-Brown-Norway donors to 6 Lewis recipients under CsA immunosuppression. Direct observation, somatosensory evoked potential test, histologic examination and microangiography were used to assess the viability of the transplants. All vascularized isotransplants and allotransplants survived over 200 days (still under observation) whereas all the nonvascularized grafts were necrosed at 7 days posttransplant. In this study the new penile allograft transplantation model in the rat was developed and a new method of blood supply to a vascularized composite tissue with directly artery-to-corpus spongiosum anastomosis was introduced.
File Format	HTM / HTML
ISSN	01487043
Issue Number	3
Volume Number	62
e-ISSN	15363708
Journal	Annals of Plastic Surgery
Language	English
Publisher	Little, Brown And Company
Publisher Date	2009-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Blood Supply Rats, Inbred Lew Rats Organ Transplantation Male Transplantation Perineum Transplantation, Homologous Journal Article Animals Discipline General Surgery Penis Microsurgery Anastomosis, Surgical Models, Animal Methods
Content Type	Text
Resource Type	Article
Subject	Surgery

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