NDLI: Efficacy of an infection control program in reducing ventilator-associated pneumonia in a Chinese neonatal intensive care unit.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Qi Lee, Shoo K. Jiang, Si-yuan Chen, Chao Kamaluddeen, Majeeda Hu, Xiao-jing Wang, Chuan-qing Cao, Yun
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Zhou Q ( Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.)
Abstract	BACKGROUND: Measures employed in preventing ventilator-associated pneumonia (VAP) in developing countries are rarely reported. This study evaluates the efficacy of an infection control program in reducing VAP in a neonatal intensive care unit (NICU) in China. METHODS: All neonates who received mechanical ventilation for at least 48 hours and were hospitalized in the NICU for ≥5 days during 3 epochs were included. The hospital relocated to a new site during phase 2 and a bundle of comprehensive preventive measures against VAP were gradually implemented using the evidence-based practice for improving quality method. Research physicians recorded associated information of patients diagnosed with VAP. RESULTS: Of 491 patients receiving mechanical ventilation, 92 (18.7%) developed VAP corresponding to 27.33 per 1,000 ventilator-days. The rate decreased from 48.84 per 1,000 ventilator-days in phase 1 to 25.73 per 1,000 ventilator-days in phase 2 and further diminished to 18.50 per 1,000 ventilator-days in phase 3 (P < .001). Overall mortality rate of admitted neonates significantly decreased from 14.0% in phase 1 to 2.9% in phase 2 and 2.7% in phase 3 (P = .000). Gram-negative bacteria (95.5%) were the predominant organisms in VAP and Acinetobacter baumannii (65.2%) was the most frequently isolated microorganism. CONCLUSIONS: Implementing a multifaceted infection control program resulted in a significant reduction in VAP rate with long-term effects. Such interventions could be extended to other low-income countries.
File Format	HTM / HTML
ISSN	01966553
Issue Number	11
Volume Number	41
e-ISSN	15273296
Journal	American Journal of Infection Control
Language	English
Publisher	Elsevier
Publisher Date	2013-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prevalence Pneumonia, Ventilator-associated Microbiology Prevention & Control Humans Infection Control Mycoses Male Epidemiology Journal Article Discipline Communicable Diseases Intensive Care Units, Neonatal Bacterial Infections China Survival Analysis Female Methods Infant, Newborn
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Public Health, Environmental and Occupational Health Epidemiology Health Policy

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