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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cleary, Brian J. Donnelly, Jean Strawbridge, Judith Gallagher, Paul J. Fahey, Tom Clarke, Mike Murphy, Deirdre J. |
| Description | Country affiliation: Ireland Author Affiliation: Cleary BJ ( Coombe Women and Infants University Hospital, Dublin 8, Ireland School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland. bcleary@coombe.ie) |
| Abstract | AIM: To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS). METHODS: PubMed, EMBASE, the Cochrane Library and PsychINFO were searched for studies reporting on methadone use in pregnancy and NAS (1966-2009). The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut-off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta-analysis. Sensitivity analyses explored the impact of limiting meta-analyses to prospective studies or studies using an objective scoring system to diagnose NAS. RESULTS: A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta-analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non-significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS. CONCLUSIONS: Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high- or low-dose methadone maintenance therapy. |
| File Format | HTM / HTML |
| ISSN | 09652140 |
| Issue Number | 12 |
| Volume Number | 105 |
| e-ISSN | 13600443 |
| Journal | Addiction |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Prenatal Exposure Delayed Effects Pregnancy Complications Humans Methadone Review Discipline Addiction Epidemiology Journal Article Opioid-related Disorders Etiology Dose-response Relationship, Drug Female Databases, Bibliographic Severity Of Illness Index Infant, Newborn Neonatal Abstinence Syndrome Adverse Effects Narcotics Drug Therapy Administration & Dosage Meta-analysis Pregnancy Randomized Controlled Trials As Topic Cohort Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
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