NDLI: Associations of CYP2A6 genotype with smoking behaviors in southern China.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Tao David, Sean P. Tyndale, Rachel F. Wang, Hui Zhou, Qian Ding, Peng He, Yan-Hui Yu, Xue-Qing Chen, Wei Crump, Casey Wen, Xiao-Zhong Chen, Wei-Qing
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Liu T ( Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, China.)
Abstract	AIMS: To investigate the association of CYP2A6 genetic polymorphisms with smoking-related phenotypes in Chinese smokers. DESIGN: Case-only genetic association study. SETTING: Southern China. PARTICIPANTS: A total of 1328 Han Chinese smokers who participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. MEASUREMENTS: All participants answered a structured questionnaire about socio-demographic status and smoking behaviors and informative alleles were genotyped for the cytochrome P450 2A6 (CYP2A6) gene (CYP2A64,5,7,9 and 10). FINDINGS: The frequencies of CYP2A64, 5, 7, 9 and 10 alleles were 8.5, 1.2, 6.3, 13.5 and 2.4%, which corresponded to 48.9, 15.4, 24.2 and 11.5% of participants being classified as normal, intermediate, slow and poor metabolizers, respectively. Multivariate analyses in male smokers demonstrated that compared with normal metabolizers, poor metabolizers reported smoking fewer cigarettes per day [adjusted odds ratio (OR) = 0.49; 95% confidence interval (CI): 0.32-0.76], started smoking regularly later in life (adjusted OR = 1.55; 95% CI: 1.06-2.26) and, among former smokers, reported smoking for a shorter duration prior to quitting (adjusted OR = 0.33; 95% CI: 0.12-0.94). However, poor metabolizers were less likely to quit smoking and remain abstinent than normal metabolizers (adjusted OR = 0.54; 95% CI: 0.34-0.86). CONCLUSIONS: Reduced metabolism function of cytochrome P450 2A6 in smokers appears to be associated with fewer cigarettes smoked, later initiation of smoking regularly, shorter smoking duration and lower likelihood of smoking cessation.
File Format	HTM / HTML
ISSN	09652140
e-ISSN	13600443
DOI	10.1111/j.1360-0443.2010.03353.x
Journal	Addiction
Issue Number	5
Volume Number	106
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-05-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Addiction Epidemiology Socioeconomic Factors Cytochrome P-450 Cyp2a6 Nicotinic Agonists Time Factors Polymerase Chain Reaction Genetics Genetic Association Studies Gene Frequency Metabolism Polymorphism, Genetic Asian Continental Ancestry Group Phenotype Epidemiologic Methods Adolescent Statistics & Numerical Data Aryl Hydrocarbon Hydroxylases Age Of Onset Smoking Nicotine Smoking Cessation
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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