NDLI: Decline in incidence of HIV and hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	de Vos, Anneke S. Van Der Helm, Jannie J. Matser, Amy Prins, Maria Kretzschmar, Mirjam E. E.
Spatial Coverage	Netherlands
Description	Country affiliation: Netherlands Author Affiliation: de Vos AS ( Julius Center, University Medical Center Utrecht, Utrecht, the Netherlands. A.S.deVos-4@umcutrecht.nl)
Abstract	AIMS: In Amsterdam, HIV prevalence has nearly halved among injecting drug users (IDU) since 1990. Hepatitis C virus (HCV) prevalence also declined; HIV and HCV incidence dropped to nearly zero. We examined possible explanations for these time trends, among which the implementation of harm reduction measures aimed at reducing the risk behaviour of IDU. DESIGN: We used individual-based modelling of the spread of HIV and HCV. Information about demographic parameters was obtained from the Amsterdam Cohort Study (ACS) among drug users. The model included changes in inflow of new IDU and death rates over time, the latter dependent on age and time since HIV seroconversion. We considered different scenarios of risk behaviour. SETTING: IDU in Amsterdam. MEASUREMENTS: Simulated HIV and HCV incidence and prevalence were compared with ACS data. FINDINGS: Assuming that harm reduction measures had led to a strong decrease in risk behaviour over time improved the model fit (squared residuals decreased by 30%). However, substantial incidence and HIV prevalence decline were already reproduced by incorporating demographic changes into the model. In particular, lowered disease spread might be a result of depletion of high-risk IDU among those at risk for disease, and a decrease in the number of high-risk individuals in the population due to HIV-related mortality. CONCLUSIONS: Marked decreases in HIV and HCV in Amsterdam since 1990 could be due partly to harm reduction measures; however, they may also be attributable largely to changes in the IDU population. Future research aimed at quantifying the benefits of interventions should not neglect the impact of natural epidemic progression and demographic changes.
File Format	HTM / HTML
ISSN	09652140
Issue Number	6
Volume Number	108
e-ISSN	13600443
Journal	Addiction
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Comparative Study Prevention & Control Humans Middle Aged Hiv Infections Substance Abuse, Intravenous Discipline Addiction Epidemiology Risk-taking Hepatitis C, Chronic Journal Article Incidence Needle Sharing Young Adult Netherlands Harm Reduction Adult Statistics & Numerical Data Cohort Studies
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Full participation in harm reduction programmes is associated with decreased risk for human immunodeficiency virus and hepatitis C virus: evidence from the Amsterdam Cohort Studies among drug users.

The effect of hepatitis C treatment and human immunodeficiency virus (HIV) co-infection on the disease burden of hepatitis C among injecting drug users in Amsterdam.

Incidence of hepatitis C virus and HIV among new injecting drug users in London: prospective cohort study.

Optimal provision of needle and syringe programmes for injecting drug users: A systematic review.

HIV and hepatitis C among injecting drug users.

Injecting drug users in Edinburgh. Fewer drug users share needles.

The role of harm reduction in controlling HIV among injecting drug users.

Survey of injecting drug users' health shows mixed picture.

Retrospective cohort study examining incidence of HIV and hepatitis C infection among injecting drug users in Dublin.

Decline in incidence of HIV and hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?

Similar Documents

Full participation in harm reduction programmes is associated with decreased risk for human immunodeficiency virus and hepatitis C virus: evidence from the Amsterdam Cohort Studies among drug users.

The effect of hepatitis C treatment and human immunodeficiency virus (HIV) co-infection on the disease burden of hepatitis C among injecting drug users in Amsterdam.

Incidence of hepatitis C virus and HIV among new injecting drug users in London: prospective cohort study.

Optimal provision of needle and syringe programmes for injecting drug users: A systematic review.

HIV and hepatitis C among injecting drug users.

Injecting drug users in Edinburgh. Fewer drug users share needles.

The role of harm reduction in controlling HIV among injecting drug users.

Survey of injecting drug users' health shows mixed picture.

Retrospective cohort study examining incidence of HIV and hepatitis C infection among injecting drug users in Dublin.

Decline in incidence of HIV and hepatitis C virus infection among injecting drug users in Amsterdam; evidence for harm reduction?