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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kuroda, Satoshi Kawabori, Masahito Hirata, Kenji Shiga, Tohru Kashiwazaki, Daina Houkin, Kiyohiro Tamaki, Nagara |
| Description | Author Affiliation: Kuroda S ( Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan, skuroda@med.u-toyama.ac.jp.) |
| Abstract | BACKGROUND: Even after the recent randomized clinical trials JET and COSS, it is still unclear that impaired cerebrovascular reactivity (CVR) to acetazolamide and oxygen extraction fraction (OEF) can identify the candidates for superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis. This prospective study was aimed to evaluate the benefits of STA-MCA 'double' anastomosis on long-term outcome in patients with reduced cerebral blood flow (CBF) and CVR (Type 3 ischemia) and elevated OEF attributable to occlusive carotid diseases. METHODS: This study included 49 patients with reduced CBF and CVR on SPECT in the ipsilateral MCA area. Using (15)O-gas PET, OEF was also measured in all patients. STA-MCA double anastomosis was recommended to the patients with Type 3 and elevated OEF. Those with Type 3 but normal OEF were medically treated. RESULTS: Of 36 patients with Type 3 and elevated OEF, 25 consented to surgery. No perioperative morbidity or mortality were noted. The other 11 patients with Type 3 and elevated OEF were medically treated. Annual incidence of ipsilateral stroke was 0.7% and 6.5% in surgically and medically treated patients with Type 3 and elevated OEF, respectively (P = 0.0188). None of patients with Type 3 but normal OEF developed ipsilateral stroke during follow-up periods. STA-MCA 'double' anastomosis significantly decreased OEF. CONCLUSIONS: STA-MCA 'double' anastomosis may still have the potential to reduce the risk of recurrent ipsilateral stroke in hemodynamically compromised patients. Further studies would be essential to advance diagnosis, surgical procedures, and perioperative managements to bring out maximal effects of bypass surgery. |
| File Format | HTM / HTML |
| ISSN | 00016268 |
| Issue Number | 1 |
| Volume Number | 156 |
| e-ISSN | 09420940 |
| Journal | Acta Neurochirurgica |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-01-01 |
| Publisher Place | Austria |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Prospective Studies Humans Middle Aged Acetazolamide Male Middle Cerebral Artery Journal Article Surgery Adult Female Physiology Diagnosis Cerebral Revascularization Clinical Trials As Topic Stroke Drug Therapy Treatment Outcome Discipline Neurosurgery Pharmacology Cerebrovascular Circulation Carotid Artery, Internal Aged, 80 And Over Drug Effects Anastomosis, Surgical Vascular Surgical Procedures Carotid Stenosis Aged Hemodynamics Methods |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery |
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