NDLI: Mechanism of dietary salt-mediated increase in intravascular production of TGF-beta1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ying, Wei-Zhong Aaron, Kristal Sanders, Paul W.
Description	Country affiliation: United States Author Affiliation: Ying WZ ( Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.)
Abstract	Clinical and preclinical studies have demonstrated an important effect of arterial pathobiology on the progressive loss of renal function that occurs in chronic kidney disease. Chronic kidney disease, in turn, promotes alterations in vascular function. A modulating role for dietary salt has been suggested, with the amount of salt intake regulating endothelial cell production of transforming growth factor-beta1 (TGF-beta1), a fibrogenic growth factor that promotes arteriosclerosis and glomerulosclerosis. The purpose of the present studies was to determine how the interaction between dietary salt intake and vasculature promoted the production of TGF-beta1 in rats. Two different vascular tissues, aortic rings and glomeruli, were chosen for study. Dietary salt induced, in a dose-dependent fashion, activation of proline-rich tyrosine kinase-2 (Pyk2) and further identified c-Src as an important binding partner of Pyk2 in these tissues. Use of pharmacological inhibitors and dominant negative strategies confirmed that dietary salt induced complex formation of Pyk2 and c-Src with downstream activation of p38 and p42/44 mitogen-activated protein kinases and generation of TGF-beta1. The experiments defined the molecular signaling events that promoted the production of TGF-beta1, a key growth factor involved in the vascular response to increased salt intake.
File Format	HTM / HTML
ISSN	1931857X
e-ISSN	15221466
DOI	10.1152/ajprenal.90294.2008
Journal	AJP: Renal Physiology
Issue Number	2
Volume Number	295
Language	English
Publisher	American Physiological Society
Publisher Date	2008-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Sodium, Dietary P38 Mitogen-activated Protein Kinases Signal Transduction Transforming Growth Factor Beta1 Mitogen-activated Protein Kinase 3 Mitogen-activated Protein Kinase 1 Rats, Sprague-dawley Discipline Nephrology Pharmacology Src-family Kinases Metabolism Focal Adhesion Kinase 2 Discipline Physiology Animals Protein-tyrosine Kinases Aorta Physiology Endothelium, Vascular
Content Type	Text
Resource Type	Article
Subject	Physiology Urology

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