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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cheng, Chen-Li de Groat, William C. |
| Description | Author Affiliation: Cheng CL ( Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. cheng20011@gmail.com) |
| Abstract | The role of 5-hydroxytryptamine (5-HT) 1A (5-HT1A) receptors in lower urinary tract function was examined in urethane-anesthetized female Sprague-Dawley rats. Bladder pressure and the external urethral sphincter electromyogram (EUS EMG) activity were recorded during continuous-infusion transvesical cystometrograms (TV-CMGs) to allow voiding and during transurethral-CMGs (TU-CMGs) which prevented voiding and allowed recording of isovolumetric bladder contractions. 8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, decreased volume threshold (VT) for initiating voiding and increased contraction amplitude (CA) during TU-CMGs but decreased CA during TV-CMGs. 8-OH-DPAT prolonged EUS bursting as well as the intrabursting silent periods (SP) during voiding. N-[2-[4-(2-methoxyphenyl)-1- piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamine trihydrochloride (WAY-100635), a 5-HT1A antagonist, increased VT, increased residual volume, markedly decreased voiding efficiency, decreased the amplitude of micturition contractions recorded under isovolumetric conditions, and decreased the SP of EUS bursting. These results indicate that activation of 5-HT1A receptors by endogenous 5-HT lowers the threshold for initiating reflex voiding and promotes voiding function by enhancing the duration of EUS relaxation, which should reduce urethral outlet resistance. |
| File Format | HTM / HTML |
| ISSN | 1931857X |
| e-ISSN | 15221466 |
| DOI | 10.1152/ajprenal.00266.2009 |
| Journal | AJP: Renal Physiology |
| Issue Number | 3 |
| Volume Number | 298 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2010-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Anesthesia, General Neuromuscular Nondepolarizing Agents 8-hydroxy-2-(di-n-propylamino)tetralin Discipline Physiology Serotonin 5-ht1 Receptor Antagonists Time Factors Electromyography Pyridines Piperazines Serotonin Pancuronium Serotonin Receptor Agonists Rats, Sprague-dawley Discipline Nephrology Serotonin 5-ht1 Receptor Agonists Pharmacology Metabolism Drug Effects Pressure Muscle Contraction Animals Serotonin Antagonists Urination Receptor, Serotonin, 5-ht1a Urinary Bladder |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Urology |
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