NDLI: Mechanotransduction in the renal tubule

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weinbaum, Sheldon Duan, Yi Satlin, Lisa M. Wang, Tong Weinstein, Alan M.
Description	Country affiliation: United States Author Affiliation: Weinbaum S ( Dept. of Biomedical Engineering, The City College of New York, New York, NY 10031, USA. weinbaum@ccny.cuny.edu)
Abstract	The role of mechanical forces in the regulation of glomerulotubular balance in the proximal tubule (PT) and Ca(2+) signaling in the distal nephron was first recognized a decade ago, when it was proposed that the microvilli in the PT and the primary cilium in the cortical collecting duct (CCD) acted as sensors of local tubular flow. In this review, we present a summary of the theoretical models and experiments that have been conducted to elucidate the structure and function of these unique apical structures in the modulation of Na(+), HCO(3)(-), and water reabsorption in the PT and Ca(2+) signaling in the CCD. We also contrast the mechanotransduction mechanisms in renal epithelium with those in other cells in which fluid shear stresses have been recognized to play a key role in initiating intracellular signaling, most notably endothelial cells, hair cells in the inner ear, and bone cells. In each case, small hydrodynamic forces need to be greatly amplified before they can be sensed by the cell's intracellular cytoskeleton to enable the cell to regulate its membrane transporters or stretch-activated ion channels in maintaining homeostasis in response to changing flow conditions.
File Format	HTM / HTML
ISSN	1931857X
e-ISSN	15221466
DOI	10.1152/ajprenal.00453.2010
Journal	AJP: Renal Physiology
Issue Number	6
Volume Number	299
Language	English
Publisher	American Physiological Society
Publisher Date	2010-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Kidney Cortex Cells, Cultured Kidney Tubules, Collecting Bicarbonates Discipline Nephrology Epithelial Cells Metabolism Microvilli Discipline Physiology Mechanotransduction, Cellular Animals Sodium Kidney Tubules, Proximal Models, Animal Physiology Mice
Content Type	Text
Resource Type	Article
Subject	Physiology Urology

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