NDLI: Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rider, Sebastien A. Mullins, Linda J. Verdon, Rachel F. MacRae, Calum A. Mullins, John J.
Description	Author Affiliation: Rider SA ( University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom); Mullins LJ ( University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom); Verdon RF ( University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom); MacRae CA ( Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.); Mullins JJ ( University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Little France, The University of Edinburgh, Edinburgh, United Kingdom)
Abstract	Although renin is a critical regulatory enzyme of the cardiovascular system, its roles in organogenesis and the establishment of cardiovascular homeostasis remain unclear. Mammalian renin-expressing cells are widespread in embryonic kidneys but are highly restricted, specialized endocrine cells in adults. With a functional pronephros, embryonic zebrafish are ideal for delineating the developmental functions of renin-expressing cells and the mechanisms governing renin transcription. Larval zebrafish renin expression originates in the mural cells of the juxtaglomerular anterior mesenteric artery and subsequently at extrarenal sites. The role of renin was determined by assessing responses to renin-angiotensin system blockade, salinity variation, and renal perfusion ablation. Renin expression did not respond to renal flow ablation but was modulated by inhibition of angiotensin-converting enzyme and altered salinity. Our data in larval fish are consistent with conservation of renin's physiological functions. Using transgenic renin reporter fish, with mindbomb and cloche mutants, we show that Notch signaling and the endothelium are essential for developmental renin expression. After inhibition of angiogenesis, renin-expressing cells precede angiogenic sprouts. Arising from separate lineages, but relying on mutual interplay with endothelial cells, renin-expressing cells are among the earliest mural cells observed in larval fish, performing both endocrine and paracrine functions.
File Format	HTM / HTML
ISSN	1931857X
e-ISSN	15221466
DOI	10.1152/ajprenal.00247.2015
Journal	AJP: Renal Physiology
Issue Number	6
Volume Number	309
Language	English
Publisher	American Physiological Society
Publisher Date	2015-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Vascular Endothelial Growth Factor Research Support, Non-u.s. Gov't Signal Transduction Discipline Nephrology Zebrafish Biosynthesis Metabolism Regional Blood Flow Antagonists & Inhibitors Discipline Physiology Receptors, Notch Renin Animals Larva Genetics Physiology Hemodynamics Endothelium, Vascular Neovascularization, Physiologic
Content Type	Text
Resource Type	Article
Subject	Physiology Urology

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