NDLI: Longitudinal changes in maternal hemodynamics in a population at risk for pre-eclampsia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Khalil, A. Garcia-Mandujano, R. Maiz, N. Elkhouli, M. Nicolaides, K. H.
Description	Country affiliation: United kingdom Author Affiliation: Khalil A ( Department of Fetal Medicine, Institute for Women's Health, University College London Hospitals, London, UK.)
Abstract	OBJECTIVE: To investigate longitudinal changes in maternal hemodynamics from the first trimester onward in women who develop pre-eclampsia (PE) or gestational hypertension (GH). METHODS: This was a prospective longitudinal study of singleton pregnancies identified by screening at 11 + 0 to 13 + 6 weeks' gestation as being at high risk for PE. Measurements of augmentation index (AIx), pulsed wave velocity (PWV) and aortic systolic blood pressure (SBPao) were taken every 4 weeks until delivery. Values were compared between women who developed preterm PE requiring delivery before 37 weeks, term PE or GH, and those who remained normotensive. RESULTS: A total of 1198 observations were recorded in 245 women, including 181 who were normotensive, 22 with preterm PE, 22 with term PE and 20 with GH. In the normotensive group, there was a U-shaped relationship between AIx and gestational age with a trough at 25 weeks' gestation, whereas changes in levels of PWV or SBPao were minimal, with a mild increase from 25 and 30 weeks' gestation onward, respectively. In the GH and preterm PE groups, compared to the normotensive group, SBPao was higher and the difference did not change significantly with gestational age. In the term PE group, SBPao did not differ significantly from that in the normotensive group. In the preterm PE group compared to the normotensive group, PWV and AIx were significantly higher from 16-17 weeks' gestation onward and the difference increased with gestational age in both cases. In the term PE and GH groups, PWV and AIx did not differ significantly from normal. CONCLUSION: This study describes temporal changes in AIx, PWV and SBPao in normotensive pregnant women and in women who develop PE or GH.
Related Links	http://onlinelibrary.wiley.com/doi/10.1002/uog.13367/full
File Format	HTM / HTML
ISSN	09607692
Volume Number	44
Journal	Ultrasound in Obstetrics & Gynecology
e-ISSN	14690705
Issue Number	2
DOI	10.1002/uog.13367
Language	English
Publisher	Wiley
Publisher Date	2014-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Obstetrics Discipline Gynecology Pre-eclampsia Diagnosis Adult Female Gestational Age Hemodynamics Humans Hypertension, Pregnancy-induced Physiopathology Longitudinal Studies Pregnancy Pregnancy Trimester, First Prospective Studies Pulse Wave Analysis Risk Assessment Ultrasonography Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Reproductive Medicine Radiological and Ultrasound Technology Obstetrics and Gynecology

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