NDLI: Risk of fetal loss associated with invasive testing following combined first-trimester screening for Down syndrome: a national cohort of 147,987 singleton pregnancies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wulff, C. B. Gerds, T. A. Rode, L. Ekelund, C. K. Petersen, O. B. Tabor, A.
Spatial Coverage	Denmark
Description	Country affiliation: Denmark Author Affiliation: Wulff CB ( Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.); Gerds TA ( Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark.); Rode L ( Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.); Ekelund CK ( Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.); Petersen OB ( Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen, Denmark.); Tabor A ( Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.)
Abstract	OBJECTIVE: To assess prospectively the risk of fetal loss associated with chorionic villus sampling (CVS) and amniocentesis (AC) following combined first-trimester screening (cFTS) for Down syndrome. METHODS: This was a nationwide population-based study (Danish Fetal Medicine Database, 2008-2010) including 147,987 women with singleton pregnancy who underwent cFTS. Propensity score stratification was used to assess the risk of fetal loss with and without invasive testing. Analyses were performed between 3 and 21 days after cFTS for CVS and between 28 and 42 days after cFTS for AC. Results are reported as average risk differences with 95% CIs. RESULTS: The risks of miscarriage and stillbirth were not higher in women exposed to CVS or AC compared with unexposed women, independent of the analysis time-point. The average effect of CVS on risk of miscarriage was -0.08% (95% CI, -0.64; 0.47) at 3 days and -0.21% (95% CI, -0.58; 0.15) at 21 days after cFTS, while the effect on risk of stillbirth was -0.18% (95% CI, -0.50; 0.13) at 3 days and -0.27% (95% CI, -0.58; 0.04) at 21 days after cFTS. Regarding the effect of AC on risk of miscarriage, the analysis at 28 days after cFTS showed an average effect of 0.56% (95% CI, -0.21; 1.33), while the effect on risk of stillbirth was 0.09% (95% CI, -0.39; 0.58) at 42 days after cFTS. CONCLUSION: Neither CVS nor AC was associated with increased risk of miscarriage or stillbirth. These findings indicate that the procedure-related risk of CVS and AC is very low.
Related Links	http://onlinelibrary.wiley.com/doi/10.1002/uog.15820/full
File Format	HTM / HTML
ISSN	09607692
Volume Number	47
Journal	Ultrasound in Obstetrics & Gynecology
e-ISSN	14690705
Issue Number	1
DOI	10.1002/uog.15820
Language	English
Publisher	Wiley
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Obstetrics Discipline Gynecology Abortion, Spontaneous Epidemiology Amniocentesis Statistics & Numerical Data Chorionic Villi Sampling Down Syndrome Diagnosis Stillbirth Adult Case-control Studies Chorionic Gonadotropin, Beta Subunit, Human Metabolism Cohort Studies Denmark Female Humans Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy-associated Plasma Protein-a Propensity Score Retrospective Studies Risk Ultrasonography, Prenatal Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Reproductive Medicine Radiological and Ultrasound Technology Obstetrics and Gynecology

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