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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cortes, Jennifer Hall, Brad Redden, Danyelle |
| Description | Author Affiliation: Cortes J ( Lakeland Regional Medical Center, Lakeland, Florida.); Hall B ( Lakeland Regional Medical Center, Lakeland, Florida.); Redden D ( Lakeland Regional Medical Center, Lakeland, Florida.) |
| Abstract | BACKGROUND: We report a case of profound symptomatic bradycardia after a single dose of tizanidine. CASE REPORT: A 93-year-old female became altered and was found to have hypotension and profound symptomatic bradycardia 30 min post ingestion of a single 4-mg dose of tizanidine at her physician's office. Emergency Medical Services was called to scene and patient was transported to our tertiary medical center. In the emergency department, the patient required intubation, vasopressor support, and transcutaneous pacing. An electrocardiogram revealed atrial fibrillation with slow ventricular response with a heart rate of 19 beats/min. The patient was transferred to the intensive care unit and subsequently taken for cardiac catheterization, where a transvenous pacer was placed. During the next few days, her vital signs and mental status improved, allowing for successful extubation. Before discharge, the patient received a single-chamber pacemaker. DISCUSSION: Profound symptomatic bradycardia from a single dose of tizanidine has not been reported. A review of the patient's medications did not reveal a significant cytochrome P450 drug interaction to result in an adverse effect as previously reported in the literature. CONCLUSIONS: Tizanidine should be used cautiously in elderly population and drug interactions screening should be performed. |
| File Format | HTM / HTML |
| ISSN | 07364679 |
| Issue Number | 4 |
| Volume Number | 48 |
| Journal | The Journal of Emergency Medicine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Emergency medicine Adrenergic Alpha-2 Receptor Agonists Adverse Effects Bradycardia Chemically Induced Clonidine Analogs & Derivatives Aged, 80 And Over Therapy Cardiac Pacing, Artificial Methods Female Humans Treatment Outcome Case Reports Journal Article |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Emergency Medicine |
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