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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Luria, Shai Waitayawinyu, Thanapong Conniff, James Morton, H. Josette Nemechek, Nicholas M. Sonnen, Joshua A. Katolik, Leonid I. Trumble, Thomas E. |
| Description | Country affiliation: United States Author Affiliation: Luria S ( Department of Orthopaedics and Sports Medicine, University Medical Center, University of Washington School of Medicine, Seattle, WA 98195-6500, USA. shail@hadassah.org.il) |
| Abstract | BACKGROUND: Protective antiself response to nervous system injury has been reported to be mediated by a T-cell subpopulation that can recognize self-antigens. Immune cells have been shown to play a role in the regulation of motor neuron survival after a peripheral nerve injury. The objective of the present study was to evaluate the effects of immune system augmentation with use of the antigen glatiramer acetate, which is known to affect T-cell immunity, on peripheral nerve regeneration. METHODS: Wild-type and nude-type (T-cell-deficient) rats underwent crush injury of the sciatic nerve. Three and six weeks after the injury, the sciatic nerve was examined, both functionally (on the basis of footprint analysis and the tibialis anterior muscle response and weight) and histologically (on the basis of axon count). RESULTS: Significantly greater muscle responses were measured after three weeks in the group of wild-type rats that were treated with glatiramer acetate (control limb:injured limb ratio, 0.05 for the glatiramer acetate group [n = 9], compared with 0.51 for the saline solution group [n = 8]; p < 0.05). Higher axon counts were also found in this group (control limb:injured limb ratio, -0.07 for the glatiramer acetate group [n = 10], compared with 0.29 for the saline solution group [n = 8]; p < 0.05). The nude-type rats showed no response to the intervention after three weeks but showed a delayed response after six weeks. A second dose of glatiramer acetate, delivered forty-eight hours after the injury, did not result in an improved response as compared with the control groups. CONCLUSIONS: We found that a single treatment with glatiramer acetate resulted in accelerated functional and histological recovery after sciatic nerve crush injury. The role of T-cell immunity in the mechanism of glatiramer acetate was suggested by the partial and late response found in the T-cell-deficient rats. |
| File Format | HTM / HTML |
| ISSN | 00219355 |
| Issue Number | 2 |
| Volume Number | 92 |
| e-ISSN | 15351386 |
| Journal | The Journal of Bone and Joint Surgery-American Volume |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2010-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Orthopedic surgery Adjuvants, Immunologic Pharmacology Immunity, Cellular Drug Effects Nerve Regeneration Immunology Peptides Sciatic Nerve Injuries Administration & Dosage Animals Dose-response Relationship, Drug Female Glatiramer Acetate Models, Animal Muscle, Skeletal Innervation Rats Rats, Nude Rats, Sprague-dawley Pathology T-lymphocytes Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Surgery Sports Science |
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