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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lyman, Stephen Nakamura, Norimasa Cole, Brian J. Erggelet, Christoph Gomoll, Andreas H. Farr, Jack |
| Description | Author Affiliation: Lyman S ( Hospital for Special Surgery Healthcare Research Institute, New York, NY lymans@hss.edu.); Nakamura N ( Department of Orthopedics, Osaka Health Science University, Osaka, Japan.); Cole BJ ( Department of Orthopedics, Rush University Medical Center, Chicago, Illinois.); Erggelet C ( Center for Biologic Joint Surgery, Department of Orthopaedic Surgery and Traumatology, University of Freiburg Medical Center, Freiburg, Germany.); Gomoll AH ( Department of Orthopaedic Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts.); Farr J ( Indiana University School of Medicine and OrthoIndy Hospital, Indianapolis, Indiana.) |
| Abstract | Articular cartilage defects strongly predispose patients to developing early joint degeneration and osteoarthritis, but for more than 15 years, no new cartilage-repair technologies that we know of have been approved by the U.S. Food and Drug Administration. Many studies examining novel approaches to cartilage repair, including cell, tissue, or matrix-based techniques, have shown great promise, but completing randomized controlled trials (RCTs) to establish safety and efficacy has been challenging, providing a major barrier to bringing these innovations into clinical use. In this article, we review reasons that surgical innovations are not well-suited for testing through RCTs. We also discuss how analytical methods for reducing bias, such as propensity scoring, make prospective observational studies a potentially viable alternative for testing the safety and efficacy of cartilage-repair and other novel therapies, offering the real possibility of therapeutic innovation. |
| File Format | HTM / HTML |
| ISSN | 00219355 |
| Issue Number | 15 |
| Journal | The Journal of Bone and Joint Surgery-American Volume |
| Volume Number | 98 |
| e-ISSN | 15351386 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2016-08-03 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Surgery Sports Science |
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