NDLI: Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus.

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Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, H-Y Hong, Y-K Yun, H-J Kim, Y-M Kim, J-R Yoo, W-H
Description	Author Affiliation: Lee HY ( Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Geumam-Dong, Deokjin-Gu, Jeonju, Jeonbuk, Korea.)
Abstract	OBJECTIVES: To determine the frequency and chemokine receptor-related migratory capacity of CD4(+)CD25(+) regulatory T cells (Tregs) and their association with clinical parameters in patients with SLE. METHODS: The expression of CD4, CD25, FoxP3 and CCR4 was examined with flow cytometry after staining with fluorescence-conjugated antibodies in 20 patients with SLE, 20 patients with RA and 21 age- and sex-matched healthy controls. For analysis of migration capacity in 24-well chemotaxis chambers, sorted cells were stimulated with ligands of CCR4, CCL17 and CCL22 and analysed with FACScan. Correlations between the number of Tregs and CCR4(+) Treg cells and clinical parameters were analysed. RESULTS: The numbers of Tregs(bright) and CCR4(+) Tregs(bright) were significantly decreased in the patients with SLE compared with healthy controls. The number of Tregs(bright) was negatively correlated with the levels of anti-dsDNA antibody and the number of CCR4(+) Tregs(bright) had a positive correlation with the levels of C(3). Percentage of migrated Tregs(bright) by CCL17 or CCL22 was significantly decreased in the patients with SLE compared with healthy controls. CONCLUSIONS: These results suggest that altered frequency of Tregs and CCR4(+) Tregs(bright) and decreased migratory capacity of Tregs might be involved in the pathogenesis of SLE and indicate that targeting the Tregs can be a new therapeutic strategy in SLE.
File Format	HTM / HTML
ISSN	14620324
e-ISSN	14620332
Journal	Rheumatology
Issue Number	6
Volume Number	47
Language	English
Publisher	Oxford University Press
Publisher Date	2008-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Rheumatology Chemotaxis, Leukocyte Immunology Lupus Erythematosus, Systemic T-lymphocytes, Regulatory Adolescent Anti-inflammatory Agents Therapeutic Use Chemokine Ccl17 Chemokine Ccl22 Forkhead Transcription Factors Blood Glucocorticoids Interleukin-2 Receptor Alpha Subunit Drug Therapy Lymphocyte Count Receptors, Ccr4 Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Rheumatology

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