NDLI: Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies.

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Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mecacci, F. Bianchi, B. Pieralli, A. Mangani, B. Moretti, A. Cioni, R. Giorgi, L. Mello, G. Matucci-Cerinic, M.
Description	Country affiliation: Italy Author Affiliation: Mecacci F ( Department of Gynaecology, Perinatology and Human Reproduction, University of Florence, Florence, Italy.)
Abstract	OBJECTIVE: Pregnant women affected by SLE are at high risk of gestational hypertension and pre-eclampsia (32-50%). This risk is particularly elevated if aPLs are dosable. The present study was planned to evaluate maternal-fetal outcomes of different groups of SLE pregnant patients characterized by diverse risk factors: patients affected by APS treated with a combination of low-dose aspirin (LDA) and low-molecular weight heparin (LMWH), nulliparous patients with dosable aPL treated by LMWH and SLE patients with no aPL administered no treatment during pregnancy. METHODS: A retrospective description of maternal and fetal outcomes was made in a total of 62 pregnancies presenting APS in 8 cases (12.9%), aPL in 20 (32.2%) and no aPL in 34 (54.8%). RESULTS: No statistically significant difference was found comparing fetal and maternal outcomes of the three groups despite differences in SLE activity: SLE aPL-positive pregnancies were associated with a higher incidence of nephritis and chronic hypertension than pregnancies treated for APS or not presenting with the added risk factor. The incidence of pre-eclampsia is 15% in aPL positive, 12.5% in APS and 14.7% in no aPL pregnancies, respectively. CONCLUSIONS: LMWH is rather a possible option of prophylaxis for SLE aPL-positive pregnancies with potential maternal-fetal outcomes similar to aPL-negative patients or to standard treated APS.
File Format	HTM / HTML
ISSN	14620324
e-ISSN	14620332
Journal	Rheumatology
Issue Number	3
Volume Number	48
Language	English
Publisher	Oxford University Press
Publisher Date	2009-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Rheumatology Antiphospholipid Syndrome Complications Lupus Erythematosus, Systemic Pregnancy Complications Drug Therapy Anticoagulants Therapeutic Use Heparin, Low-molecular-weight Pregnancy Pregnancy Outcome Retrospective Studies
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Rheumatology

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