NDLI: Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Thijssen, Eva Van Caam, Arjan Van Der Kraan, Peter M.
Description	Country affiliation: Netherlands Author Affiliation: Thijssen E ( Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.); van Caam A ( Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.); van der Kraan PM ( Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands peter.vanderkraan@radboudumc.nl.)
Abstract	OA is a degenerative joint disease characterized by articular cartilage degradation, osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk factors is obesity. To date, it is not fully understood how obesity results in OA. Historically, this link was ascribed to excessive joint loading as a result of increased body weight. However, the association between obesity and OA in non-weight-bearing joints suggests a more complex aetiology for obesity-induced OA. In the present review, the link between obesity and OA is discussed. First, the historical view of altered joint loading leading to wear and tear of the joint is addressed. Subsequently, the effects of a disturbed lipid metabolism, low-grade inflammation, and adipokines on joint tissues are discussed and linked to OA. Taken together, inflamed adipose tissue and dyslipidaemia play pivotal roles in obesity-induced OA. It becomes increasingly clear that the link between obesity and OA transcends excessive loading.
File Format	HTM / HTML
ISSN	14620324
e-ISSN	14620332
Journal	Rheumatology
Issue Number	4
Volume Number	54
Language	English
Publisher	Oxford University Press
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Rheumatology Adipose Tissue Immunology Dyslipidemias Metabolism Obesity Osteoarthritis Adipokines Cartilage, Articular Complications Inflammation Lipid Peroxidation Etiology Synovial Membrane Weight-bearing Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Rheumatology

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