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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Forcheron, Fabien Abdallah, Pauline Basset, Alexandra Del Carmine, Peggy Haffar, Ghina Beylot, Michel |
| Description | Country affiliation: France Author Affiliation: Forcheron F ( INSERM ERI 22 EA 4173, Faculté Rockefeller, Lyon, France.) |
| Abstract | No specific treatment for nonalcoholic hepatic fatty liver disease has been defined. We followed the spontaneous evolution of liver steatosis and tested the therapeutic usefulness of metformin and fenofibrate in a model of steatosis, the Zucker diabetic fatty (ZDF) rat. ZDF and control rats were studied at 7, 14, and 21 weeks. After initial study at 7 weeks, ZDF rats received no treatment, metformin or fenofibrate until studies at 14 or 21 weeks. ZDF rats were obese, hypertriglyceridemic, insulin resistant at 7 weeks, type 2 diabetic at 14, diabetic with insulin deficiency at 21. They had steatosis at 7 weeks with increased hepatic expression and activity of lipogenesis. Steatosis was unchanged at 14 and 21 weeks despite lower expression and activity of lipogenesis. Metformin and fenofibrate did not modify energy intake or expenditure or the evolution of diabetes. Both compounds decreased plasma triacylglycerol (TAG) concentrations. Hepatic TAG content was reduced by fenofibrate at 14 and 21 weeks but only at 21 weeks by metformin. Metformin had no significant effects on the expression in liver of genes of fatty acids metabolism. The beneficial effect of fenofibrate occurred despite increased expression of genes involved in the uptake and activation of fatty acids. Acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I (CPTI) mRNA levels were increased by fenofibrate showing evidence of increased lipid oxidation. To conclude, metformin had only moderate effects on liver steatosis. The effects of fenofibrate was more marked but remained mild. |
| File Format | HTM / HTML |
| ISSN | 19307381 |
| Issue Number | 7 |
| Volume Number | 17 |
| e-ISSN | 1930739X |
| Journal | Obesity |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Diabetes Mellitus, Experimental Complications Fatty Liver Drug Therapy Etiology Fenofibrate Therapeutic Use Hypoglycemic Agents Hypolipidemic Agents Metformin Animals Blood Glucose Metabolism Body Weight Drug Effects Disease Models, Animal Eating Energy Metabolism Fatty Acids Pharmacology Insulin Blood Male Ppar Alpha Agonists Rna, Messenger Rats Rats, Zucker Triglycerides Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology |
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