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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ciangura, Cecile Bouillot, Jean-Luc Lloret-Linares, Celia Poitou, Christine Veyrie, Nicolas Basdevant, Arnaud Oppert, Jean-Michel |
| Description | Country affiliation: France Author Affiliation: Ciangura C ( Department of Nutrition, Pitié-Salpêtrière Hospital (AP-HP), University Pierre et Marie Curie-Paris6, Human Nutrition Research Center (CRNH-Ile de France), Paris, France.) |
| Abstract | Little is known on patterns of change over time in body composition, especially lean body mass (LBM), during massive weight loss after Roux-en-Y gastric bypass (RYGB) in obese patients. We performed sequential measurements of total and regional body composition in patients after RYGB, and we compared a subsample of patients after surgery to a nonsurgical control group of similar age and body fatness. We used dual-energy X-ray absorptiometry (DXA) before and at 3, 6, and 12 months after RYGB in 42 obese women (before surgery: age 39.5 +/- 11.6 years; BMI 44.6 +/- 6.1 kg/m(2); mean +/- s.d.) and in 48 control obese women referred for nonsurgical weight management, before weight loss. During 1-year follow-up after RYGB, there was a continuous decrease in body weight (-36.0 +/- 12.5 kg at 1 year), total fat mass (FM) (-26.0 +/- 9.1 kg), as well as in trunk and appendicular FM. In contrast, the decrease in total LBM (-9.8 +/- 4.8 kg at 1 year), as well as in trunk and appendicular LBM, plateaued after 3-6 months. Rates of loss in weight, FM, and LBM were highest during the first 3-month period after RYGB (6.4 +/- 1.8, 4.1 +/- 1.7, and 2.3 +/- 1.2 kg/month, respectively), then decreased continuously for FM but plateaued for LBM. There was no evidence of a decrease in total, trunk, or appendicular LBM in weight-reduced subjects compared to the control group. In conclusion, follow-up of these obese women revealed a differential pattern of change in FM and LBM after RYGB. Despite an important loss in LBM, especially during the 3-6 months of initial period, LBM appears to be spared thereafter. |
| File Format | HTM / HTML |
| ISSN | 19307381 |
| Issue Number | 4 |
| Volume Number | 18 |
| e-ISSN | 1930739X |
| Journal | Obesity |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Adipose Tissue Adiposity Body Composition Body Weight Gastric Bypass Obesity Surgery Absorptiometry, Photon Adult Analysis Of Variance Case-control Studies Female Follow-up Studies Humans Middle Aged Physiopathology Treatment Outcome Weight Loss Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology |
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