NDLI: Dietary Whey Protein Decreases Food Intake and Body Fat in Rats

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, June Keenan, Michael J. Losso, Jack N. Raggio, Anne M. Shen, Li McCutcheon, Kathleen L. Tulley, Richard T. Blackman, Marc R. Martin, Roy J.
Description	Country affiliation: United States Author Affiliation: Zhou J ( Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA. june.zhou@va.gov)
Abstract	We investigated the effects of dietary whey protein on food intake, body fat, and body weight gain in rats. Adult (11-12 week) male Sprague-Dawley rats were divided into three dietary treatment groups for a 10-week study: control. Whey protein (HP-W), or high-protein content control (HP-S). Albumin was used as the basic protein source for all three diets. HP-W and HP-S diets contained an additional 24% (wt/wt) whey or isoflavone-free soy protein, respectively. Food intake, body weight, body fat, respiratory quotient (RQ), plasma cholecystokinin (CCK), glucagon like peptide-1 (GLP-1), peptide YY (PYY), and leptin were measured during and/or at the end of the study. The results showed that body fat and body weight gain were lower (P < 0.05) at the end of study in rats fed HP-W or HP-S vs. control diet. The cumulative food intake measured over the 10-week study period was lower in the HP-W vs. control and HP-S groups (P < 0.01). Further, HP-W fed rats exhibited lower N(2) free RQ values than did control and HP-S groups (P < 0.01). Plasma concentrations of total GLP-1 were higher in HP-W and HP-S vs. control group (P < 0.05), whereas plasma CCK, PYY, and leptin did not differ among the three groups. In conclusion, although dietary HP-W and HP-S each decrease body fat accumulation and body weight gain, the mechanism(s) involved appear to be different. HP-S fed rats exhibit increased fat oxidation, whereas HP-W fed rats show decreased food intake and increased fat oxidation, which may contribute to the effects of whey protein on body fat.
File Format	HTM / HTML
ISSN	19307381
e-ISSN	1930739X
DOI	10.1038/oby.2011.14
Journal	Obesity
Issue Number	8
Volume Number	19
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Adipose Tissue Drug Effects Dietary Proteins Pharmacology Energy Intake Energy Metabolism Milk Proteins Soybean Proteins Weight Gain Metabolism Animals Glucagon-like Peptide 1 Blood Lipid Peroxidation Nitrogen Rats, Sprague-dawley Whey Proteins Comparative Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology

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