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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ortinau, L. C. Nickelson, K. J. Stromsdorfer, K. L. Naik, C. Y. Pickering, R. T. Haynes, R. A. Fritsche, K. L. Perfield, J. W. |
| Description | Country affiliation: United States Author Affiliation: Ortinau LC ( Department of Food Science, University of Missouri-Columbia, Columbia, Missouri, USA.) |
| Abstract | OBJECTIVE: Abnormal lipid metabolism and excess accumulation of lipid in non-adipose tissues are defining characteristics of obesity and its comorbidities. Expression and/or activity of stearoyl-CoA desaturase-1 (SCD1), a major regulator of lipid metabolism, is increased with obesity and the reduction/ablation of this enzyme is associated with an improved metabolic profile. Sterculic oil (SO), obtained from the seeds of the Sterculia feotida tree, contains a high concentration of cyclopropenoic fatty acids which are known inhibitors of SCD1. The purpose of this study was to determine the effects of SO supplementation on the development of obesity and insulin resistance in hyperphagic, obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats. DESIGN & METHODS: Rats received either an AIN-93G diet (control) or an AIN-93G diet containing 0.5% SO for 10 weeks. RESULTS: SO did not alter body weight or body composition. Importantly, the desaturase indices, a proxy for the activity of SCD1, were reduced in the liver and adipose tissue of SO supplemented animals. This reduction in SCD1 activity was associated with a reduction in fasting blood glucose concentrations and improved glucose tolerance. In addition, SO reduced intra-abdominal fat mass and adipocyte size and resulted in a â¼3-fold increase in GLUT1 gene expression in intra-abdominal fat. Liver triglyceride content and lipogenic gene expression were reduced by SO. Consistent with an improved metabolic phenotype, SO also improved plasma cholesterol, LDL-cholesterol, and triglyceride concentrations. CONCLUSION: Overall, our data demonstrate an improved metabolic phenotype with SO supplementation and suggest further studies are required to better understand the therapeutic potential of SO. |
| File Format | HTM / HTML |
| ISSN | 19307381 |
| Issue Number | 2 |
| Volume Number | 21 |
| e-ISSN | 1930739X |
| Journal | Obesity |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Dietary Supplements Lipid Metabolism Drug Effects Plant Oils Pharmacology Stearoyl-coa Desaturase Metabolism Sterculia Chemistry Adipocytes Animals Blood Glucose Analysis Body Composition Body Weight Cholesterol, Ldl Blood Diet Insulin Resistance Intra-abdominal Fat Pathology Liver Male Obesity Drug Therapy Rats Rats, Inbred Oletf Antagonists & Inhibitors Triglycerides Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology |
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