NDLI: Effect of dietary composition of weight loss diets on high-sensitivity c-reactive protein: the Randomized POUNDS LOST trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nicklas, Jacinda M. Sacks, Frank M. Smith, Steven R. LeBoff, Meryl S. Rood, Jennifer C. Bray, George A. Ridker, Paul M.
Description	Country affiliation: United States Author Affiliation: Nicklas JM ( Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline, Massachusetts, USA. jnicklas1@partners.org)
Abstract	OBJECTIVE: Overweight and obesity are associated with increased high-sensitivity C-reactive protein (hsCRP) levels. The purpose of this study was to determine if weight loss diets differing in fat, protein, or carbohydrate composition differentially reduce hsCRP. DESIGN AND METHODS: POUNDS (preventing overweight using novel dietary strategies) LOST was a 2-year trial of overweight and obese adults randomly allocated to one of four weight loss diets with targeted percentages of energy derived from fat, protein, and carbohydrates (20, 15, 65%; 20, 25, 55%; 40, 15, 45%; 40, 25, 35%, respectively). hsCRP was measured at baseline, 6, and 24 months among 710 participants, and adiposity as measured by dual X-ray absorptiometry (N = 340) or abdominal computed tomography (N = 126) was correlated with hsCRP change. RESULTS: At 6 months, hsCRP was reduced in all trial participants by -24.7% (Interquartile range (IQR) +7%, -50%), weight by -6.7% (IQR -3%, -11%), and waist circumference by -6.0% (IQR -3%, -10%) (all P < 0.002), with no significant differences according to dietary composition. The percent change in hsCRP at 6 and 24 months correlated modestly with change in weight, waist circumference, fasting insulin, fasting glucose, HOMA, and most lipid levels. Reductions in hsCRP persisted despite â¼ 50% regain of weight by 24 months. The percent change in hsCRP at 24 months significantly correlated with changes in total body fat (r = 0.42), total abdominal adiposity (r = 0.52), subcutaneous abdominal adiposity (r = 0.52), visceral adiposity (r = 0.47), and hepatic tissue density (r = -0.34) (all P < 0.0006). CONCLUSION: Weight loss decreased hsCRP by similar magnitude, irrespective of dietary composition. Clinicians concerned about inflammation and cardiovascular risk should recommend weight loss diets most likely to succeed for their patients.
File Format	HTM / HTML
ISSN	19307381
e-ISSN	1930739X
DOI	10.1002/oby.20072
Journal	Obesity
Issue Number	4
Volume Number	21
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Endocrinology C-reactive Protein Metabolism Diet, Reducing Dietary Carbohydrates Administration & Dosage Dietary Fats Dietary Proteins Absorptiometry, Photon Adipose Tissue Chemistry Drug Effects Adiposity Biological Markers Blood Blood Glucose Body Composition Body Mass Index Body Weight Cholesterol Fasting Insulin Obesity Diet Therapy Waist Circumference Randomized Controlled Trial Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Endocrinology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of Dietary Composition of Weight Loss Diets on High Sensitivity C-Reactive Protein: The Randomized POUNDS LOST Trial

Effect of diet composition and weight loss on resting energy expenditure in the POUNDS LOST study.

Step-Defined Physical Activity Is Associated With Weight Loss and Changes in Body Composition and Fat Distribution in Response to Diet Interventions: The POUNDS Lost Trial

Normal vs. high-protein weight loss diets in men: effects on body composition and indices of metabolic syndrome.

Dietary fiber and associations with adiposity and fasting insulin among college students with plausible dietary reports.

Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.

Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner.

Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results.

Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans.

Effect of dietary composition of weight loss diets on high-sensitivity c-reactive protein: the Randomized POUNDS LOST trial.

Similar Documents

Effect of Dietary Composition of Weight Loss Diets on High Sensitivity C-Reactive Protein: The Randomized POUNDS LOST Trial

Effect of diet composition and weight loss on resting energy expenditure in the POUNDS LOST study.

Step-Defined Physical Activity Is Associated With Weight Loss and Changes in Body Composition and Fat Distribution in Response to Diet Interventions: The POUNDS Lost Trial

Normal vs. high-protein weight loss diets in men: effects on body composition and indices of metabolic syndrome.

Dietary fiber and associations with adiposity and fasting insulin among college students with plausible dietary reports.

Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.

Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner.

Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results.

Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans.

Effect of dietary composition of weight loss diets on high-sensitivity c-reactive protein: the Randomized POUNDS LOST trial.