NDLI: The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bajic, Vladan P. Spremo-Potparevic, Biljana Zivkovic, Lada Bonda, David J. Siedlak, Sandra L. Casadesus, Gemma Lee, Hyoung-Gon Smith, Mark A.
Description	Author Affiliation: Bajic VP ( Institute of Biomedical Research, Galenika ad, 11000 Belgrade, Serbia. vladanbajic@yahoo.com)
Abstract	Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelerated aging of the affected brain.
File Format	HTM / HTML
ISSN	03069877
e-ISSN	15322777
DOI	10.1016/j.mehy.2009.06.046
Journal	Medical Hypotheses
Issue Number	6
Volume Number	73
Language	English
Publisher	Elsevier
Publisher Date	2009-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Medical theory Aging Genetics Alzheimer Disease Chromosomal Instability Chromosomes, Human, X Dna Replication Phenotype Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine

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The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?

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