NDLI: Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity.

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Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity.

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Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pandey, Jyotsana Maurya, Ranjani Raykhera, Rahul Srivastava, Mahendra N. Yadav, Prem P. Tamrakar, Akhilesh K.
Description	Country affiliation: India Author Affiliation: Pandey J ( Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.)
Abstract	BACKGROUND: Murraya koenigii (L.) Spreng. is an important medicinal plant used traditionally as an antiemetic, antidiarrhoeal agent and blood purifier and as a medicine for a variety of ailments. This study investigated the effects of ethanolic extract of M. koenigii (MK) on diabetes-associated insulin resistance induced in mice by chronic low-dose injection of dexamethasone. RESULTS: Mice treated with dexamethasone exhibited hyperglycaemia and impaired glucose tolerance. Treatment with MK reduced the extent of dexamethasone-induced hyperglycaemia and decreased insulin resistance as indicated by improved glucose tolerance and increased insulin-stimulated AKT phosphorylation in skeletal muscle tissue. Further evaluation in clonal skeletal muscle cell lines suggested that MK increased glucose uptake in L6 skeletal muscle cells by increasing cell surface GLUT4 density via an AKT-mediated pathway. CONCLUSION: MK can ameliorate dexamethasone-induced hyperglycaemia and insulin resistance in part by increasing glucose disposal into skeletal muscle.
File Format	HTM / HTML
ISSN	00225142
Issue Number	11
Volume Number	94
e-ISSN	10970010
Journal	Journal of the Science of Food and Agriculture
Language	English
Publisher	Wiley
Publisher Date	2014-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Agriculture Blood Glucose Metabolism Glucose Intolerance Drug Therapy Hyperglycemia Insulin Resistance Murraya Muscle Fibers, Skeletal Drug Effects Phytotherapy Animals Dexamethasone Blood Chemically Induced Glucose Transporter Type 4 Insulin Male Mice Phosphorylation Plant Extracts Pharmacology Therapeutic Use Plant Leaves Proto-oncogene Proteins C-akt Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Food Science Biotechnology Agronomy and Crop Science

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Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity.