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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wu, Gang Bao, Xuhui Xi, Guohua Keep, Richard F. Thompson, B. Gregory Hua, Ya |
| Description | Country affiliation: United States Author Affiliation: Wu G ( Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109-2200, USA.) |
| Abstract | OBJECT: Hypertension is the main cause of spontaneous intracerebral hemorrhages (ICHs), but the effects of hypertension on ICH-induced brain injury have not been well studied. In this study, the authors examined ICH-induced brain injury in spontaneously hypertensive rats (SHRs). METHODS: This 2-part study was performed in 12-week-old male SHRs and Wistar Kyoto (WKY) rats. First, the rats received an intracaudate injection of 0.3 U collagenase, and hematoma sizes were determined at 24 hours. Second, rats were injected with 100 µl autologous whole blood into the right basal ganglia. Brain edema, neuronal death, ferritin expression, microglia activation, and neurological deficits were examined. RESULTS: Hematoma sizes were the same in SHR and WKY rats 24 hours after collagenase injection. The SHRs had greater neuronal death and neurological deficits after blood injection. Intracerebral hemorrhage also resulted in higher brain ferritin levels and stronger activation of microglia in SHRs. However, perihematomal brain edema was the same in the SHRs and WKY rats. CONCLUSIONS: Moderate chronic hypertension resulted in more severe ICH-induced neuronal death and neurological deficits, but did not exaggerate hematoma enlargement and perihematomal brain edema in the rat ICH models. |
| File Format | HTM / HTML |
| ISSN | 00223085 |
| e-ISSN | 19330693 |
| DOI | 10.3171/2011.1.JNS101530 |
| Journal | Journal of Neurosurgery |
| Issue Number | 6 |
| Volume Number | 114 |
| Language | English |
| Publisher | American Association of Neurological Surgeons |
| Publisher Date | 2011-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Neurosurgery Brain Injuries Etiology Brain Metabolism Cerebral Hemorrhage Complications Animals Blood Pressure Physiology Blotting, Western Brain Edema Disease Models, Animal Ferritins Immunohistochemistry Rats, Inbred Shr Rats, Inbred Wky Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery |
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