NDLI: Glioblastoma therapy in the elderly and the importance of the extent of resection regardless of age.

Please wait, while we are loading the content...

Year: 2017 Volume: 126

Year: 2016 Volume: 2016

Year: 2016 Volume: 125

Year: 2016 Volume: 124

Year: 2015 Volume: 123

Year: 2015 Volume: 123 Spec Suppl

Year: 2015 Volume: 122

Year: 2014 Volume: 121

Year: 2014 Volume: 120

Year: 2013 Volume: 119

Year: 2013 Volume: 118

Year: 2012 Volume: 117

Year: 2012 Volume: 116

Year: 2012 Volume: 116 Issue: 6

Year: 2012 Volume: 116 Issue: 5

Year: 2012 Volume: 116 Issue: 4

Year: 2012 Volume: 116 Issue: 3

Year: 2012 Volume: 116 Issue: 2

Factors associated with delay to pituitary adenoma diagnosis in patients with visual loss.

Disparities in care.

Fibromatosis: a potential sequela of neuromuscular choristoma.

Return of spinal reflex after spinal cord surgery for brachial plexus avulsion injury.

Recruitment by SDF-1 of CD34-positive cells involved in sciatic nerve regeneration.

C5-8 brachial plexus root injury: the 'T-1 hand'.

Invasion of the corticotrophs.

Prospective evaluation of the characteristics and incidence of adenoma-associated dural invasion in Cushing disease.

Results after treatment of craniopharyngiomas: further experiences with 73 patients since 1997.

Glioblastoma therapy in the elderly and the importance of the extent of resection regardless of age.

Glioblastoma in the elderly.

The history of pituitary surgery for Cushing disease.

The quiet revolution: retractorless surgery for complex vascular and skull base lesions.

Adipose lesions of nerve: the need for a modified classification.

Retractorless brain surgery.

Natural history and surgical management of incidentally discovered low-grade gliomas.

Motor cortex disinhibition in normal-pressure hydrocephalus.

Microendoscopic stereotactic-guided percutaneous radiofrequency trigeminal nucleotractotomy.

Avastin: more questions than answers. . .

Kenneth Grant Jamieson (1925-1976): his life and contributions to neurosurgery.

A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma.

Atypia predicting prognosis for intracranial extraventricular neurocytomas.

Clinical data simplified.

Association fibers connecting the Broca center and the lateral superior frontal gyrus: a microsurgical and tractographic anatomy.

A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.

An episode of severely suppressed electrocerebral activity recorded by electroencephalography during endoscopic resection of a colloid cyst.

The constant flow ventricular infusion test: a simple and useful study in the diagnosis of third ventriculostomy failure.

Deep brain stimulation and depression.

Percutaneous biopsy of lesions in the cavernous sinus region through the foramen ovale: diagnostic accuracy and limits in 50 patients.

Deep brain stimulation interruption and suicidality.

Craniovertebral junction abnormalities with hindbrain herniation and syringomyelia: regression of syringomyelia after removal of ventral craniovertebral junction compression.

Retinoblastoma.

Normal pressure hydrocephalus.

Low-grade gliomas.

Ganglion cyst of the temporomandibular joint with intracranial extension in a patient presenting with seventh cranial nerve palsy.

Year: 2012 Volume: 116 Issue: 1

Year: 2011 Volume: 115

Year: 2011 Volume: 114

Year: 2010 Volume: 113

Year: 2010 Volume: 112

Year: 2009 Volume: 111

Glioblastoma therapy in the elderly and the importance of the extent of resection regardless of age.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oszvald, Agi Güresir, Erdem Setzer, Matthias Vatter, Hartmut Senft, Christian Seifert, Volker Franz, Kea
Description	Country affiliation: Germany Author Affiliation: Oszvald A ( Department of Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.)
Abstract	OBJECT: The objective of this study was to analyze whether age influences the outcome of patients with glioblastoma and whether elderly patients with glioblastoma can tolerate the same aggressive treatment as younger patients. METHODS: Data from 361 consecutive patients with newly diagnosed cerebral glioblastoma (2000-2006) who underwent regular follow-up evaluation from initial diagnosis until death were prospectively entered into a database. Patients underwent resection (complete, subtotal, or partial) or biopsy, depending on tumor size, location, and Karnofsky Performance Scale score. Following surgery, all patients underwent adjuvant treatment consisting of radiotherapy, chemotherapy, or combined treatment. Patients older than 65 years of age were defined as elderly (146 total). RESULTS: Two hundred thirty-four patients underwent tumor resection (complete 26%, subtotal 29%, and partial 45%). One hundred twenty-seven underwent biopsy. Mean patient age was 61 years, and overall survival was 11.6 ± 12.1 months. The overall survival of elderly patients (9.1 ± 11.6 months) was significantly lower than that of younger patients (14.9 ± 16.7 months; p = 0.0001). Stratifying between resection or biopsy, age was a negative prognostic factor in patients undergoing biopsy (4.0 ± 7.1 vs 7.9 ± 8.7 months; p = 0.007), but not in patients undergoing tumor resection (13.0 ± 8.5 vs 13.3 ± 14.5 months; p = 0.86). Survival of elderly patients undergoing complete tumor resection was 17.7 ± 8.1 months. CONCLUSIONS: In this series of patients with glioblastoma, age was a prognostic factor in patients undergoing biopsy, but not in patients undergoing resection. Tumor location and patient clinical status may prohibit extensive resection, but resection should not be withheld from patients only on the basis of age. In elderly patients with glioblastoma, undergoing resection to the extent feasible, followed by adjuvant therapies, is warranted.
File Format	HTM / HTML
ISSN	00223085
e-ISSN	19330693
Journal	Journal of Neurosurgery
Issue Number	2
Volume Number	116
Language	English
Publisher	American Association of Neurological Surgeons
Publisher Date	2012-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurosurgery Brain Neoplasms Brain Pathology Surgery Glioblastoma Adolescent Age Distribution Biopsy Mortality Therapy Databases, Factual Disease Progression Predictive Value Of Tests Prejudice Prognosis Risk Factors Survival Analysis
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Surgery

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in