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  1. Journal of Investigative Dermatology
  2. Year: 2004 Volume: 122
  3. Year: 2004 Volume: 122 Issue: 2
  4. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
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Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.
Year: 2003 Volume: 121
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Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.

Content Provider World Health Organization (WHO)-Global Index Medicus
Author Tsao, Hensin Goel, Vikas Wu, Heng Yang, Guang Haluska, Frank G.
Description Country affiliation: United States Author Affiliation: Tsao H ( Wellman Laboratories, Department of Dermatology, Massachusetts General Hospital Melanoma Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.)
Abstract Extant evidence implicates growth factor signaling in the pathogenesis of many tumor types, including cutaneous melanoma. Recently, reciprocal activating mutations of NRAS and BRAF were found in benign melanocytic nevi and cutaneous melanomas. We had previously reported a similar epistatic relationship between activating NRAS mutations and inactivating PTEN/MMAC1 alterations. We thus hypothesized that BRAF and PTEN/MMAC1 mutations may cooperate to promote melanoma tumorigenesis. Overall, 40 of 47 (85%) melanoma cell lines and 11 of 16 (69%) uncultured melanoma metastases had mutations in NRAS, BRAF, or PTEN/MMAC1. NRAS was exclusively mutated in nine of 47 (19%) cell lines and two of 16 (13%) metastases, whereas BRAF was solely mutated in 28 of 47 (60%) cell lines and nine of 16 (56%) metastases. In the 12 of 15 melanoma cell lines (80%) and two of two melanoma metastases with PTEN alterations, BRAF was also mutated. These findings suggest the existence of possible cooperation between BRAF activation and PTEN loss in melanoma development.
File Format HTM / HTML
ISSN 0022202X
e-ISSN 15231747
Journal Journal of Investigative Dermatology
Issue Number 2
Volume Number 122
Language English
Publisher Elsevier
Publisher Date 2004-02-01
Publisher Place United States
Access Restriction Open
Subject Keyword Discipline Dermatology Melanoma Genetics Phosphoric Monoester Hydrolases Proto-oncogene Proteins C-raf Skin Neoplasms Tumor Suppressor Proteins Ras Proteins Cell Line, Tumor Gene Expression Regulation, Neoplastic Pten Phosphohydrolase Metabolism Polymorphism, Single-stranded Conformational Proto-oncogene Proteins B-raf Signal Transduction Physiology Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s.
Content Type Text
Resource Type Article
Subject Cell Biology Biochemistry Molecular Biology Dermatology
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