NDLI: Expression of the stem cell markers nestin and CD133 on circulating melanoma cells.

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Expression of the stem cell markers nestin and CD133 on circulating melanoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fusi, Alberto Reichelt, Uta Busse, Antonia Ochsenreither, Sebastian Rietz, Anika Maisel, Markus Keilholz, Ulrich
Description	Country affiliation: Germany Author Affiliation: Fusi A ( Department of Hematology and Medical Oncology, Charité, Campus Benjamin Franklin, Berlin, Germany.)
Abstract	Different molecular markers have been identified for melanoma-initiating cells including CD133 and nestin. Assuming that metastasis requires a dissemination of tumor-initiating cells, presence of circulating tumor-initiating cells should be associated with worse patient outcome. In this study, 20 ml blood was collected from 32 consecutive patients affected by metastatic melanoma and blood was enriched for circulating melanoma cells (CMCs) by CD45 depletion of the non-melanoma cell fraction. Multiparameter cytometry was carried out to co-stain with combinations of CD133 and nestin (NES). Six tissue samples from metastatic lesions of six different patients were stained with the same antibodies by immunohistochemistry. Percentage of NES-positive CMCs correlated with tumor burden and number of metastatic sites. Cox regression analysis revealed levels of lactate dehydrogenase (LDH; hazard ratio: 12.8 (1.35-121.5); P=0.02), number of metastatic sites (hazard ratio 3.87 (1.66-9.03); P=0.02), tumor burden (hazard ratio 5.72 (1.57-20.9); P=0.01), and percentage of NES-expressing CMCs ≥ 35% (hazard ratio 5.73 (1.66-19.7); P=0.006) to be factors related to shorter overall survival. CD133- and NES-expression profiles on CMCs were similar to matched metastatic tissue. These findings show that CMCs expressed stem cell-associated markers NES and CD133. Higher expression of NES on CMCs might represent an index of poor prognosis.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
Journal	Journal of Investigative Dermatology
Issue Number	2
Volume Number	131
Language	English
Publisher	Elsevier
Publisher Date	2011-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Antigens, Cd Metabolism Tumor Markers, Biological Glycoproteins Intermediate Filament Proteins Melanoma Nerve Tissue Proteins Peptides Skin Neoplasms Kaplan-meier Estimate L-lactate Dehydrogenase Mortality Pathology Neoplasm Staging Nestin Predictive Value Of Tests Prognosis Regression Analysis Survival Rate Tumor Burden Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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