NDLI: Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sulk, Mathias Seeliger, Stephan Aubert, Jerome Schwab, Verena D. Cevikbas, Ferda Rivier, Michel Nowak, Pawel Voegel, Johannes J. Buddenkotte, Jörg Steinhoff, Martin
Description	Country affiliation: Germany Author Affiliation: Sulk M ( Department of Dermatology, University Hospital Münster, Münster, Germany.)
Abstract	Rosacea is a frequent chronic inflammatory skin disease of unknown etiology. Because early rosacea reveals all characteristics of neurogenic inflammation, a central role of sensory nerves in its pathophysiology has been discussed. Neuroinflammatory mediators and their receptors involved in rosacea are poorly defined. Good candidates may be transient receptor potential (TRP) ion channels of vanilloid type (TRPV), which can be activated by many trigger factors of rosacea. Interestingly, TRPV2, TRPV3, and TRPV4 are expressed by both neuronal and non-neuronal cells. Here, we analyzed the expression and distribution of TRPV receptors in the various subtypes of rosacea on non-neuronal cells using immunohistochemistry, morphometry, double immunoflourescence, and quantitative real-time PCR (qRT-PCR) as compared with healthy skin and lupus erythematosus. Our results show that dermal immunolabeling of TRPV2 and TRPV3 and gene expression of TRPV1 is significantly increased in erythematotelangiectatic rosacea (ETR). Papulopustular rosacea (PPR) displayed an enhanced immunoreactivity for TRPV2, TRPV4, and also of TRPV2 gene expression. In phymatous rosacea (PhR)-affected skin, dermal immunostaining of TRPV3 and TRPV4 and gene expression of TRPV1 and TRPV3 was enhanced, whereas epidermal TRPV2 staining was decreased. Thus, dysregulation of TRPV channels also expressed by non-neuronal cells may be critically involved in the initiation and/or development of rosacea. TRP ion channels may be targets for the treatment of rosacea.
File Format	HTM / HTML
ISSN	0022202X
e-ISSN	15231747
DOI	10.1038/jid.2011.424
Journal	Journal of Investigative Dermatology
Issue Number	4
Volume Number	132
Language	English
Publisher	Elsevier
Publisher Date	2012-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Dermatology Rosacea Metabolism Skin Trpv Cation Channels Antigens, Cd Antigens, Differentiation, Myelomonocytic Biopsy Case-control Studies Lupus Erythematosus, Systemic Pathology Tryptases Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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