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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meephansan, Jitlada Tsuda, Hidetoshi Komine, Mayumi Tominaga, Shin-Ichi Ohtsuki, Mamitaro |
| Description | Country affiliation: Japan Author Affiliation: Meephansan J ( Department of Dermatology, Jichi Medical University, Tochigi, Japan.) |
| Abstract | IL-33, a member of the IL-1 family, is implicated in type 2 T helper cell immune reactions and acts as an 'alarmin' to induce activation of dendritic cells in response to external stimuli. We investigated the effect of inflammatory cytokines on IL-33 expression in normal human epidermal keratinocytes. IFN-γ dose- and time-dependently induced IL-33 expression in protein and mRNA; this was dependent on extracellular signal-regulated kinase, p38, EGFR, and JAK phosphorylation. Combined IFN-γ and tumor necrosis factor (TNF)- treatment induced expression of a 20-kDa band corresponding to mature IL-33, which was abolished by the addition of a calpain inhibitor. The addition of the inhibitor to IFN-γ and TNF- -stimulated cells also induced strong expression of a 25-kDa band. Small interference (si) RNA for IL-33 abolished expression of the smaller bands and the 30-kDa IL-33 band, suggesting that these IL-33 forms were IL-33 transcription products. Recombinant IL-33 added in the medium induced IL-8 production, and RNA knockdown by siRNA enhanced IL-8 expression, suggesting its dual role as a cytokine and a nuclear factor. These results indicate that IL-33 has a role in inflammatory skin diseases, in which IFN-γ and TNF- are present in high levels. |
| File Format | HTM / HTML |
| ISSN | 0022202X |
| e-ISSN | 15231747 |
| Journal | Journal of Investigative Dermatology |
| Issue Number | 11 |
| Volume Number | 132 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Dermatology Interferon-gamma Metabolism Interleukins Genetics Keratinocytes Immunology Skin Diseases Tumor Necrosis Factor-alpha Calpain Cells, Cultured Dermatitis, Atopic Epidermis Cytology Foreskin Gene Expression Infant, Newborn Pharmacology Interleukin-33 Interleukin-8 Drug Effects Lichen Planus Map Kinase Signaling System Psoriasis Rna Interference Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology Dermatology |
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