| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Kamo, Atsuko Tominaga, Mitsutoshi Kamata, Yayoi Kaneda, Kazuyuki Ko, Kyi C. Matsuda, Hironori Kimura, Utako Ogawa, Hideoki Takamori, Kenji |
| Description |
Country affiliation: Japan Author Affiliation: Kamo A ( 1] Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan [2] Department of Nursing, School of Health Sciences, Tokai University, Kanagawa, Japan.); Tominaga M ( Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan.); Kamata Y ( Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan.); Kaneda K ( Ushio Inc., Tokyo, Japan.); Ko KC ( Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan.); Matsuda H ( Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan.); Kimura U ( Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.); Ogawa H ( Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan.); Takamori K ( 1] Institute for Environmental and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Chiba, Japan [2] Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.) |
| Abstract |
Epidermal hyperinnervation, which is thought to underlie intractable pruritus, has been observed in patients with atopic dermatitis (AD). The epidermal expression of axonal guidance molecules has been reported to regulate epidermal hyperinnervation. Previously, we showed that the excimer lamp has antihyperinnervative effects in nonpruritic dry-skin model mice, although epidermal expression of axonal guidance molecules was unchanged. Therefore, we investigated the antipruritic effects of excimer lamp irradiation and its mechanism of action. A single irradiation of AD model mice significantly inhibited itch-related behavior 1 day later, following improvement in the dermatitis score. In addition, irradiation of nerve fibers formed by cultured dorsal root ganglion neurons increased bleb formation and decreased nerve fiber expression of nicotinamide mononucleotide adenylyl transferase 2, suggesting degenerative changes in these fibers. We also analyzed whether attaching a cutoff excimer filter (COF) to the lamp, thus decreasing cytotoxic wavelengths, altered hyperinnervation and the production of cyclobutane pyrimidine dimer (CPD), a DNA damage marker, in dry-skin model mice. Irradiation with COF decreased CPD production in keratinocytes, as well as having an antihyperinnervative effect, indicating that the antipruritic effects of excimer lamp irradiation with COF are due to induction of epidermal nerve degeneration and reduced DNA damage. |
| File Format |
HTM / HTML |
| ISSN |
0022202X |
| e-ISSN |
15231747 |
| Journal |
Journal of Investigative Dermatology |
| Issue Number |
12 |
| Volume Number |
134 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-12-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Dermatology Dermatitis, Atopic Radiotherapy Lasers, Excimer Therapeutic Use Nerve Degeneration Etiology Pruritus Skin Animals Dna Damage Radiation Effects Complications Disease Models, Animal Ganglia, Spinal Keratinocytes Metabolism Pathology Mice Mice, Inbred Icr Nicotinamide-nucleotide Adenylyltransferase Pyrimidine Dimers Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Cell Biology Biochemistry Molecular Biology Dermatology |
