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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kikuchi, Kaori Itoh, Yoshiharu Tateoka, Ryoko Ezawa, Atsuko Murakami, Kenjiro Niwa, Toshimitsu |
| Description | Country affiliation: Japan Author Affiliation: Kikuchi K ( Biomedical Research Laboratories, Kureha Corporation, Tokyo, Japan.) |
| Abstract | We applied the metabolomic analysis of comprehensive small-molecular metabolites using liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) and principal component analysis to identify uremic toxins accumulated in the serum of chronic renal failure (CRF) rats. CRF rats were produced by 5/6-nephrectomy. Indoxyl sulfate was demonstrated to be the first principal serum metabolite which differentiates CRF from normal, followed by phenyl sulfate, hippuric acid and p-cresyl sulfate. Then, we measured the serum levels of indoxyl sulfate, phenyl sulfate, hippuric acid and p-cresyl sulfate by the selected reaction monitoring (SRM) of LC/ESI-MS/MS, and demonstrated that these serum levels were markedly increased in CRF rats as compared with normal rats. As creatinine clearance decreased, the serum levels of the metabolites increased. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Issue Number | 20 |
| Volume Number | 878 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-06-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Chromatography, Liquid Methods Kidney Failure, Chronic Blood Metabolomics Spectrometry, Mass, Electrospray Ionization Toxins, Biological Animals Cresols Disease Models, Animal Hippurates Humans Indican Kidney Chemistry Urine Male Rats Rats, Sprague-dawley Sulfuric Acid Esters Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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