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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tan, Zhirong Ouyang, Dongsheng Chen, Yao Zhou, Gan Cao, Shan Wang, Yicheng Peng, Xiujuan Zhou, Honghao |
| Description | Author Affiliation: Tan Z ( Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Xiangya Road 110, Changsha, Hunan 410078, PR China.) |
| Abstract | A sensitive and specific liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) method has been developed and validated for the identification and quantification of clebopride in human plasma using itopride as an internal standard. The method involves a simple liquid-liquid extraction. The analytes were separated by isocratic gradient elution on a CAPCELL MG-III C(18) (5 microm, 150 mm x 2.1 mm i.d.) column and analyzed in multiple reaction monitoring (MRM) mode with positive electrospray ionization (ESI) interface using the respective [M+H](+) ions, m/z 373.9-->m/z184.0 for clebopride, m/z 359.9-->m/z71.5 for itopride. The method was validated over the concentration range of 69.530-4450.0 pg/ml for clebopride. Within- and between-batch precision (RSD%) was all within 6.83% and accuracy ranged from -8.16 to 1.88%. The LLOQ was 69.530 pg/ml. The extraction recovery was on an average 77% for clebopride. The validated method was used to study the pharmacokinetics profile of clebopride in human plasma after oral administration of clebopride. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Issue Number | 23 |
| Volume Number | 878 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Antiemetics Blood Pharmacokinetics Asian Continental Ancestry Group Benzamides Chromatography, Liquid Methods Health Administration, Oral Administration & Dosage Chemistry Benzyl Compounds Drug Stability Humans Limit Of Detection Male Quality Control Reference Standards Reproducibility Of Results Time Factors Clinical Trial Journal Article Research Support, Non-u.s. Gov't Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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