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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jourdil, Jean-François Tonini, Julia Stanke-Labesque, Françoise |
| Description | Country affiliation: France Author Affiliation: Jourdil JF ( CHU, Hôpital A. Michallon, Laboratoire de pharmacologie-toxicologie, BP217, Grenoble F-38043, France. JFJourdil@chu-grenoble.fr) |
| Abstract | High-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard analytical technique for therapeutic drug monitoring (TDM). A rapid LC-MS/MS method was developed for simultaneous quantitation of 3 antifungals and one active metabolite (posaconazole, voriconazole, itraconazole, and hydroxy-itraconazole), 5 antibiotics (daptomycin, ciprofloxacin, oxacillin, levofloxacin, and rifampicin), an antineoplastic agent (imatinib), and an antiretroviral (raltegravir) in human plasma. Protein precipitation of 10 µL of plasma with acetonitrile was used as a single-extraction procedure. After 2-dimensional LC, all drugs were quantified by electrospray ionization-triple quadrupole mass spectrometry by selected reaction monitoring detection in the positive mode. The method was validated per FDA recommendations including the study of extraction recovery (from 79.3% to 105.9%) and matrix effect via ion suppression/enhancement phenomenon. This method is precise (intra- and inter-assay coefficients of variation of 1.95-12.77%, 2.56-8.16% and 2.12-11.38% for low, medium and high levels of internal quality controls respectively) and accurate (intra- and inter-assay biases of 0.19-12.67%, 0.04 to -12.17% and 0.22-12.98% respectively). This method is an efficient tool for routine TDM and optimization of laboratory resource utilization. |
| File Format | HTM / HTML |
| ISSN | 15700232 |
| Volume Number | 919-920 |
| e-ISSN | 1873376X |
| Journal | Journal of Chromatography B |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Chemistry Anti-bacterial Agents Blood Antifungal Agents Azoles Benzamides Chromatography, High Pressure Liquid Methods Piperazines Pyrimidines Pyrrolidinones Antineoplastic Agents Drug Stability Humans Imatinib Mesylate Least-squares Analysis Limit Of Detection Raltegravir Potassium Reproducibility Of Results Tandem Mass Spectrometry Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
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