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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Korenfeld, Michael S. Silverstein, Steven M. Cooke, David L. Vogel, Roger Crockett, Robert S. |
| Description | Country affiliation: United States Author Affiliation: Korenfeld MS ( Comprehensive Eye Care Ltd., 901 East 3rd Street, Washington, Missouri 63090, USA. michaelkorenfeld@hotmail.com) |
| Abstract | PURPOSE: To assess the efficacy and safety of difluprednate ophthalmic emulsion 0.05% (Durezol) 2 or 4 times a day compared with those of a placebo in the treatment of inflammation and pain associated with ocular surgery. SETTING: Twenty-six clinics in the United States. METHODS: One day after unilateral ocular surgery, patients who had an anterior chamber cell grade of 2 or higher (>10 cells) were treated with 1 drop of difluprednate 2 times or 4 times a day or with a placebo (vehicle) 2 times or 4 times a day in the study eye for 14 days. This was followed by a 14-day tapering period and a 7-day safety evaluation. Outcome measures included cleared anterior chamber inflammation (grade 0, or=10 mm Hg and >or=21 mm Hg from baseline, respectively) versus 1% in the placebo group. CONCLUSIONS: Difluprednate given 2 or 4 times a day cleared postoperative inflammation and reduced pain rapidly and effectively. There were no serious ocular adverse events. Fewer adverse events were reported in the difluprednate-treated groups than in the placebo group. |
| File Format | HTM / HTML |
| ISSN | 08863350 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 18734502 |
| Journal | Journal of Cataract & Refractive Surgery |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Fluprednisolone Analogs & Derivatives Glucocorticoids Administration & Dosage Pain Drug Therapy Postoperative Complications Uveitis, Anterior Adult Aged Aged, 80 And Over Anterior Chamber Drug Effects Pathology Cell Count Double-blind Method Emulsions Female Adverse Effects Humans Inflammation Male Middle Aged Ophthalmic Solutions Ophthalmologic Surgical Procedures Physiopathology Clinical Trial, Phase Iii Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Surgery |
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