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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | He, Xiaoyin Spoerl, Eberhard Tang, Junhua Liu, Jun |
| Description | Country affiliation: United States Author Affiliation: He X ( Department of Biomedical Engineering, Ohio State University, Columbus, Ohio, USA.) |
| Abstract | PURPOSE: To determine the changes in corneal properties induced by riboflavin-ultraviolet A (UVA) irradiation using a noninvasive ultrasound (US) method in a porcine eye model. SETTING: Department of Biomedical Engineering, Ohio State University, Columbus, Ohio, USA. METHODS: Fresh porcine globes acquired within 24 hours postmortem were divided into equal groups. In the collagen crosslinking (CXL) group, the globes were irradiated with UVA in combination with riboflavin application following the standard protocol. The control group had the same procedures as the CXL group but with no UVA irradiation. Corneal properties were measured before and after treatments in both groups using a quantitative US method. Changes in corneal thickness, density, and stiffness were examined and the difference between the changes in the CXL group and the control group was analyzed. RESULTS: Each group comprised 14 porcine globes. After riboflavin-UVA treatment, there was a significant increase in corneal stiffness (mean 2.59 +/- 0.08 GPa before and 2.70 +/- 0.08 GPa after CXL) (P<.001) and in the speed of sound in corneal tissue (1557 +/- 23 m/s versus 1588 +/- 22 m/s) (P<.001). There was no significant change in corneal stiffness or in the speed of sound in the control group. Corneal thickness increased significantly after the treatment in both groups. No significant change in corneal density was observed in either group. CONCLUSION: Corneal stiffness increased after riboflavin-UVA CXL, a finding detected using a noninvasive US technique. FINANCIAL DISCLOSURE: Dr. Liu has filed a patent application for the general ultrasound technique used in the study. No other author has a financial or proprietary interest in any material or method mentioned. |
| File Format | HTM / HTML |
| ISSN | 08863350 |
| Issue Number | 7 |
| Volume Number | 36 |
| e-ISSN | 18734502 |
| Journal | Journal of Cataract & Refractive Surgery |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Collagen Metabolism Corneal Stroma Drug Effects Photochemotherapy Photosensitizing Agents Pharmacology Riboflavin Animals Biomechanical Phenomena Radiation Effects Elasticity Swine Ultrasonography Ultraviolet Rays Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Surgery |
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