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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aydemir, Orhan Güler, Mete Kaya, Mehmet Kaan Deniz, Nurettin Üstündag, Bilal |
| Description | Country affiliation: Turkey Author Affiliation: Aydemir O ( Department of Ophthalmology, School of Medicine, Firat University, Elazig, Turkey.) |
| Abstract | PURPOSE: To determine whether ebselen has a protective effect or antioxidative potential in a sodium-selenite-induced experimental cataract model. SETTING: Firat University, Elazig, Turkey. DESIGN: Experimental study. METHODS: Twenty-one Sprague-Dawley rat pups were randomly divided into a control group, a sodium-selenite-induced-cataract group, and an ebselen-treated group; each group contained 7 rat pups. Rats in the control group received dimethyl sulfoxide (DMSO) intraperitoneally only and rats in the sodium-selenite-induced-cataract group received 30 nmol/g body weight sodium selenite subcutaneously and DMSO intraperitoneally 10 days postpartum. Rats in the ebselen group received 30 nmol/g body weight sodium selenite subcutaneously 10 days postpartum and were treated with 5 mg/kg body weight ebselen once a day for 4 consecutive days. Cataract development was assessed weekly for 3 weeks by slitlamp examination and graded using a scale. Reduced glutathione (GSH), total nitrite, and malondialdehyde (MDA) levels in lens supernatants were measured at the end of 3 weeks. RESULTS: In the control group, all lenses were clear. In the ebselen-treated group, the mean cataract stage was significantly lower than in the sodium-selenite-induced-cataract group (P = .022). The GSH levels were significantly lower in the sodium-selenite-induced-cataract group than in the control and ebselen groups (P < .001). The MDA levels were lower in the ebselen group than in the sodium-selenite-induced-cataract group (P < .001). The mean total nitrite level was significantly lower in the sodium-selenite-induced-cataract group than in the ebselen group (P = .001). CONCLUSIONS: Ebselen had a protective effect on cataract development in a sodium-selenite-induced experimental model. The protective effect of ebselen appears to be due to inhibition of oxidative stress. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned. |
| File Format | HTM / HTML |
| ISSN | 08863350 |
| Issue Number | 12 |
| Volume Number | 38 |
| e-ISSN | 18734502 |
| Journal | Journal of Cataract & Refractive Surgery |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Antioxidants Therapeutic Use Azoles Cataract Prevention & Control Disease Models, Animal Lens, Crystalline Drug Effects Organoselenium Compounds Animals Chemically Induced Metabolism Pathology Glutathione Malondialdehyde Nitrites Oxidative Stress Rats Rats, Sprague-dawley Sodium Selenite Toxicity Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology Sensory Systems Surgery |
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