NDLI: Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Musoke, Philippa M. Young, Alicia M. Owor, Maxensia A. Lubega, Irene R. Brown, Elizabeth R. Mmiro, Francis A. Mofenson, Lynne M. Jackson, J. Brooks Fowler, Mary Glenn Guay, Laura A.
Spatial Coverage	Uganda
Description	Country affiliation: Uganda Author Affiliation: Musoke PM ( Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda. pmusoke@mujhu.org)
Abstract	OBJECTIVES: To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %. DESIGN: This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV-infected children in the HIV Network for Prevention Trials 012 trial. METHODS: TLC and CD4 cell % measurements were obtained at birth, 14 weeks, and 12, 24, 36, 48, and 60 months of age and assessed with respect to risk of death within 12 months. RESULTS: Median TLC per microliter (CD4 cell %) was 4150 (41%) at birth, 4900 (24%) at 12 months, 4300 (19%) at 24 months, 4150 (19%) at 36 months, 4100 (18%) at 48 months, and 3800 (20%) at 60 months. The highest risk of mortality within 12 months was 34% - 37% at birth and declined to 13%-15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC was extremely low overall (r = 0.01). CONCLUSIONS: The TLC did not predict a risk of progression to death within 12 months in HIV-infected Ugandan children. Therefore, TLC alone may not be a useful surrogate marker for determining those children at highest risk of death, who require antiretroviral therapy most urgently.
File Format	HTM / HTML
ISSN	15254135
e-ISSN	10779450
DOI	10.1097/QAI.0b013e318183a92a
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Issue Number	2
Volume Number	49
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline AIDS Hiv Infections Diagnosis Mortality Biological Markers Cd4 Lymphocyte Count Child, Preschool Immunology Infant Infant, Newborn Longitudinal Studies Lymphocyte Count Prognosis Retrospective Studies Uganda Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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